Publikation:

Phenylalanine hydroxylase-stimulating protein/pterin-4alpha-carbinolamine dehydratase from rat and human liver : purification, characterization, and complete amino acid sequence

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Phenylalanine_hydroxylase_stimulating_protein.pdf
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Datum

1993

Autor:innen

Hauer, Charles R.
Rebrin, Igor
Thöny, Beat
Neuheiser, Frank
Curtius, Hans-Christoph
Hunziker, Peter
Blau, Nenad
Heizmann, Claus W.

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http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-52962
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Attribution-NonCommercial-NoDerivs 2.0 Generic

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Open Access Green

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Biologie: Publikationen
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Published

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Journal of Biological Chemistry. 1993, 268(7), pp. 4828-4831

Zusammenfassung

Phenylalanine hydroxylase-stimulating protein, also known as pterin-4α-carbinolamine dehydratase (PHS/PCD), was purified from rat and, for the first time, from human liver. We obtained their complete protein primary sequence using a combination of liquid secondary ionization mass spectrometry/tandem quadrupole mass spectrometry, electrospray ionization mass spectrometry, and Edman microsequence analysis. The amino acid sequences of human and rat PHS/PCD were found to be identical. Surprisingly, the primary structure of PHS/PCD is also essentially identical to a protein of the cell nucleus, named dimerization cofactor of hepatocyte nuclear factor 1α, recently reported to be involved in transcription (Mendel, D. M., Khavari, P. A., Conley, P. B., Graves, M. K., Hansen, L. P., Admon, A., and Crabtree, G. R. (1991) Science 254, 1762-1767).

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570 Biowissenschaften, Biologie

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ISO 690HAUER, Charles R., Igor REBRIN, Beat THÖNY, Frank NEUHEISER, Hans-Christoph CURTIUS, Peter HUNZIKER, Nenad BLAU, Sandro GHISLA, Claus W. HEIZMANN, 1993. Phenylalanine hydroxylase-stimulating protein/pterin-4alpha-carbinolamine dehydratase from rat and human liver : purification, characterization, and complete amino acid sequence. In: Journal of Biological Chemistry. 1993, 268(7), pp. 4828-4831
BibTex
@article{Hauer1993Pheny-6995,
  year={1993},
  title={Phenylalanine hydroxylase-stimulating protein/pterin-4alpha-carbinolamine dehydratase from rat and human liver : purification, characterization, and complete amino acid sequence},
  number={7},
  volume={268},
  journal={Journal of Biological Chemistry},
  pages={4828--4831},
  author={Hauer, Charles R. and Rebrin, Igor and Thöny, Beat and Neuheiser, Frank and Curtius, Hans-Christoph and Hunziker, Peter and Blau, Nenad and Ghisla, Sandro and Heizmann, Claus W.}
}
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