Phenylalanine hydroxylase-stimulating protein/pterin-4alpha-carbinolamine dehydratase from rat and human liver : purification, characterization, and complete amino acid sequence

Lade...
Vorschaubild
Dateien
Datum
1993
Autor:innen
Hauer, Charles R.
Rebrin, Igor
Thöny, Beat
Neuheiser, Frank
Curtius, Hans-Christoph
Hunziker, Peter
Blau, Nenad
Heizmann, Claus W.
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
DOI (zitierfähiger Link)
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Open Access Green
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Zusammenfassung

Phenylalanine hydroxylase-stimulating protein, also known as pterin-4α-carbinolamine dehydratase (PHS/PCD), was purified from rat and, for the first time, from human liver. We obtained their complete protein primary sequence using a combination of liquid secondary ionization mass spectrometry/tandem quadrupole mass spectrometry, electrospray ionization mass spectrometry, and Edman microsequence analysis. The amino acid sequences of human and rat PHS/PCD were found to be identical. Surprisingly, the primary structure of PHS/PCD is also essentially identical to a protein of the cell nucleus, named dimerization cofactor of hepatocyte nuclear factor 1α, recently reported to be involved in transcription (Mendel, D. M., Khavari, P. A., Conley, P. B., Graves, M. K., Hansen, L. P., Admon, A., and Crabtree, G. R. (1991) Science 254, 1762-1767).

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690HAUER, Charles R., Igor REBRIN, Beat THÖNY, Frank NEUHEISER, Hans-Christoph CURTIUS, Peter HUNZIKER, Nenad BLAU, Sandro GHISLA, Claus W. HEIZMANN, 1993. Phenylalanine hydroxylase-stimulating protein/pterin-4alpha-carbinolamine dehydratase from rat and human liver : purification, characterization, and complete amino acid sequence. In: Journal of Biological Chemistry. 1993, 268(7), pp. 4828-4831
BibTex
@article{Hauer1993Pheny-6995,
  year={1993},
  title={Phenylalanine hydroxylase-stimulating protein/pterin-4alpha-carbinolamine dehydratase from rat and human liver : purification, characterization, and complete amino acid sequence},
  number={7},
  volume={268},
  journal={Journal of Biological Chemistry},
  pages={4828--4831},
  author={Hauer, Charles R. and Rebrin, Igor and Thöny, Beat and Neuheiser, Frank and Curtius, Hans-Christoph and Hunziker, Peter and Blau, Nenad and Ghisla, Sandro and Heizmann, Claus W.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/6995">
    <dc:contributor>Heizmann, Claus W.</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/6995/1/Phenylalanine_hydroxylase_stimulating_protein.pdf"/>
    <dc:contributor>Rebrin, Igor</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/2.0/"/>
    <dcterms:issued>1993</dcterms:issued>
    <dc:creator>Hunziker, Peter</dc:creator>
    <dcterms:title>Phenylalanine hydroxylase-stimulating protein/pterin-4alpha-carbinolamine dehydratase from rat and human liver : purification, characterization, and complete amino acid sequence</dcterms:title>
    <dc:creator>Heizmann, Claus W.</dc:creator>
    <dc:creator>Blau, Nenad</dc:creator>
    <dc:creator>Hauer, Charles R.</dc:creator>
    <dc:format>application/pdf</dc:format>
    <dc:language>eng</dc:language>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/6995"/>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:contributor>Thöny, Beat</dc:contributor>
    <dc:creator>Rebrin, Igor</dc:creator>
    <dc:creator>Thöny, Beat</dc:creator>
    <dc:creator>Neuheiser, Frank</dc:creator>
    <dc:creator>Ghisla, Sandro</dc:creator>
    <dc:contributor>Hauer, Charles R.</dc:contributor>
    <dc:contributor>Neuheiser, Frank</dc:contributor>
    <dc:contributor>Blau, Nenad</dc:contributor>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/6995/1/Phenylalanine_hydroxylase_stimulating_protein.pdf"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Curtius, Hans-Christoph</dc:contributor>
    <dc:creator>Curtius, Hans-Christoph</dc:creator>
    <dc:contributor>Hunziker, Peter</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:30:43Z</dc:date>
    <dcterms:abstract xml:lang="eng">Phenylalanine hydroxylase-stimulating protein, also known as pterin-4α-carbinolamine dehydratase (PHS/PCD), was purified from rat and, for the first time, from human liver. We obtained their complete protein primary sequence using a combination of liquid secondary ionization mass spectrometry/tandem quadrupole mass spectrometry, electrospray ionization mass spectrometry, and Edman microsequence analysis. The amino acid sequences of human and rat PHS/PCD were found to be identical. Surprisingly, the primary structure of PHS/PCD is also essentially identical to a protein of the cell nucleus, named dimerization cofactor of hepatocyte nuclear factor 1α, recently reported to be involved in transcription (Mendel, D. M., Khavari, P. A., Conley, P. B., Graves, M. K., Hansen, L. P., Admon, A., and Crabtree, G. R. (1991) Science 254, 1762-1767).</dcterms:abstract>
    <dc:contributor>Ghisla, Sandro</dc:contributor>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:30:43Z</dcterms:available>
    <dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights>
    <dcterms:bibliographicCitation>First publ. in: Journal of Biological Chemistry 268 (1993), 7, pp. 4828-4831</dcterms:bibliographicCitation>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Diese Publikation teilen