Publikation:

Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice

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2011

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http://nbn-resolving.de/urn:nbn:de:bsz:352-186016
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https://doi.org/10.1371/journal.pone.0017869
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PLoS ONE. 2011, 6(3), e17869. eISSN 1932-6203. Available under: doi: 10.1371/journal.pone.0017869

Zusammenfassung

The anticancer activity of titanium complexes has been known since the groundbreaking studies of Ko¨ pf and Ko¨ pf-Maier on titanocen dichloride. Unfortunately, possibly due to their fast hydrolysis, derivatives of titanocen dichloride failed in clinical studies. Recently, the new family of titanium salan complexes containing tetradentate ONNO ligands with anti-cancer properties has been discovered. These salan complexes are much more stabile in aqueous media. In this study we describe the biological activity of two titanium salan complexes in a mouse model of cervical cancer. High efficiency of this promising complex family was demonstrated for the first time in vivo. From these data we conclude that titanium salan complexes display very strong antitumor properties exhibiting only minor side effects. Our results may influence the chemotherapy with metallo therapeutics in the future.

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540 Chemie

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ISO 690IMMEL, Timo, Ulrich GROTH, Thomas HUHN, Peter ÖHLSCHLÄGER, 2011. Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice. In: PLoS ONE. 2011, 6(3), e17869. eISSN 1932-6203. Available under: doi: 10.1371/journal.pone.0017869
BibTex
@article{Immel2011Titan-18601,
  year={2011},
  doi={10.1371/journal.pone.0017869},
  title={Titanium salan complexes displays strong antitumor properties in vitro and in vivo in mice},
  number={3},
  volume={6},
  journal={PLoS ONE},
  author={Immel, Timo and Groth, Ulrich and Huhn, Thomas and Öhlschläger, Peter},
  note={Article Number: e17869}
}
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