Morphogen transport

Lade...
Vorschaubild
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
2013
Autor:innen
Rogers, Katherine W.
Yu, Shuizi R.
Brand, Michael
Schier, Alexander F.
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
DOI (zitierfähiger Link)
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Development. Company of Biologists. 2013, 140(8), pp. 1621-1638. ISSN 0950-1991. eISSN 1477-9129. Available under: doi: 10.1242/dev.083519
Zusammenfassung

The graded distribution of morphogens underlies many of the tissue patterns that form during development. How morphogens disperse from a localized source and how gradients in the target tissue form has been under debate for decades. Recent imaging studies and biophysical measurements have provided evidence for various morphogen transport models ranging from passive mechanisms, such as free or hindered extracellular diffusion, to cell-based dispersal by transcytosis or cytonemes. Here, we analyze these transport models using the morphogens Nodal, fibroblast growth factor and Decapentaplegic as case studies. We propose that most of the available data support the idea that morphogen gradients form by diffusion that is hindered by tortuosity and binding to extracellular molecules.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
Morphogen, Gradient, Diffusion, Cytoneme, Signaling
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690MÜLLER, Patrick, Katherine W. ROGERS, Shuizi R. YU, Michael BRAND, Alexander F. SCHIER, 2013. Morphogen transport. In: Development. Company of Biologists. 2013, 140(8), pp. 1621-1638. ISSN 0950-1991. eISSN 1477-9129. Available under: doi: 10.1242/dev.083519
BibTex
@article{Muller2013-04Morph-56288,
  year={2013},
  doi={10.1242/dev.083519},
  title={Morphogen transport},
  number={8},
  volume={140},
  issn={0950-1991},
  journal={Development},
  pages={1621--1638},
  author={Müller, Patrick and Rogers, Katherine W. and Yu, Shuizi R. and Brand, Michael and Schier, Alexander F.}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/56288">
    <dcterms:abstract xml:lang="eng">The graded distribution of morphogens underlies many of the tissue patterns that form during development. How morphogens disperse from a localized source and how gradients in the target tissue form has been under debate for decades. Recent imaging studies and biophysical measurements have provided evidence for various morphogen transport models ranging from passive mechanisms, such as free or hindered extracellular diffusion, to cell-based dispersal by transcytosis or cytonemes. Here, we analyze these transport models using the morphogens Nodal, fibroblast growth factor and Decapentaplegic as case studies. We propose that most of the available data support the idea that morphogen gradients form by diffusion that is hindered by tortuosity and binding to extracellular molecules.</dcterms:abstract>
    <dc:creator>Rogers, Katherine W.</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/56288"/>
    <dcterms:title>Morphogen transport</dcterms:title>
    <dc:contributor>Schier, Alexander F.</dc:contributor>
    <dc:rights>terms-of-use</dc:rights>
    <dc:language>eng</dc:language>
    <dc:creator>Müller, Patrick</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-01-21T11:54:18Z</dcterms:available>
    <dc:creator>Brand, Michael</dc:creator>
    <dc:creator>Yu, Shuizi R.</dc:creator>
    <dc:creator>Schier, Alexander F.</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dcterms:issued>2013-04</dcterms:issued>
    <dc:contributor>Brand, Michael</dc:contributor>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Rogers, Katherine W.</dc:contributor>
    <dc:contributor>Yu, Shuizi R.</dc:contributor>
    <dc:contributor>Müller, Patrick</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-01-21T11:54:18Z</dc:date>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Nein
Begutachtet
Ja
Diese Publikation teilen