Attenuation of the cytotoxic T lymphocyte response to lymphocytic choriomeningitis virus in mice subjected to chronic social stress

Sommershof, Annette; Basler, Michael; Riether, Carsten; Engler, Harald; Gröttrup, Marcus

Attenuation of the cytotoxic T lymphocyte response to lymphocytic choriomeningitis virus in mice subjected to chronic social stress

Dateien

Sommershof_Attenuation.pdfGröße: 5.06 MBDownloads: 710

Datum

2011

Autor:innen

Sommershof, Annette

Basler, Michael

Riether, Carsten

Engler, Harald

Gröttrup, Marcus

Publikationstyp

Zeitschriftenartikel

unikn.publication.listelement.citation.prefix.version.undefined

Brain, Behavior, and Immunity. 2011, 25(2), pp. 340-348. ISSN 0889-1591. eISSN 1090-2139. Available under: doi: 10.1016/j.bbi.2010.10.016

Zusammenfassung

Chronic stress is suspected to increase the susceptibility to infections but experimental evidence from physiological stress models is scarce. We examined the effects of chronic social stress on virus-specific CTL responses in mice after infection with lymphocytic choriomeningitis virus (LCMV). Mice subjected to social stress on six consecutive days prior to infection showed a significant reduction of IFN-γ producing TCD8+ splenocytes and markedly lowered plasma concentrations of IFN-γ. In contrast, the generation of LCMV-specific CTL responses was not altered in mice undergoing the same stress procedure concurrently with infection. Furthermore, stress exposure 6 days before and additional 3 days after LCMV infection profoundly reduced the expansion of TCD8+ cells in the spleen, due to diminished in vivo proliferation. Pharmacological blockade of glucocorticoid receptors completely abrogated the stress-associated decline of TCD8+ expansion. Stressed mice showed a significantly reduced expression of the early T-cell activation marker CD69 as well as impaired in vitro cytokine secretion of IFN-γ and IL-2. Additionally, social stress led to an altered migration capacity of TCD8+ cells as demonstrated by adoptive T cell transfer experiments. Taken together, this study shows that chronic social stress fundamentally suppresses the functional capacities of T cells during a viral infection.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Schlagwörter

Cytotoxic T cells, viral infection, social stress, corticosterone, dendritic cells

Zitieren

ISO 690

SOMMERSHOF, Annette, Michael BASLER, Carsten RIETHER, Harald ENGLER, Marcus GRÖTTRUP, 2011. Attenuation of the cytotoxic T lymphocyte response to lymphocytic choriomeningitis virus in mice subjected to chronic social stress. In: Brain, Behavior, and Immunity. 2011, 25(2), pp. 340-348. ISSN 0889-1591. eISSN 1090-2139. Available under: doi: 10.1016/j.bbi.2010.10.016

BibTex

@article{Sommershof2011-02Atten-16318,
  year={2011},
  doi={10.1016/j.bbi.2010.10.016},
  title={Attenuation of the cytotoxic T lymphocyte response to lymphocytic choriomeningitis virus in mice subjected to chronic social stress},
  number={2},
  volume={25},
  issn={0889-1591},
  journal={Brain, Behavior, and Immunity},
  pages={340--348},
  author={Sommershof, Annette and Basler, Michael and Riether, Carsten and Engler, Harald and Gröttrup, Marcus}
}

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