rTMS Induced Tinnitus Relief Is Related to an Increase in Auditory Cortical Alpha Activity

Müller, Nadia; Lorenz, Isabel; Langguth, Berthold; Weisz, Nathan

rTMS Induced Tinnitus Relief Is Related to an Increase in Auditory Cortical Alpha Activity

Files

Mueller_2-3anhk4jf3ew09.pdf(1.08 MB)

Date

2013

Authors

Müller, Nadia

Lorenz, Isabel

Langguth, Berthold

Weisz, Nathan

Publication type

Journal article

Publication status

Published

Published in

PLoS one ; 8 (2013), 2. - e55557. - eISSN 1932-6203

Abstract

Chronic tinnitus, the continuous perception of a phantom sound, is a highly prevalent audiological symptom. A promising approach for the treatment of tinnitus is repetitive transcranial magnetic stimulation (rTMS) as this directly affects tinnitus-related brain activity. Several studies indeed show tinnitus relief after rTMS, however effects are moderate and vary strongly across patients. This may be due to a lack of knowledge regarding how rTMS affects oscillatory activity in tinnitus sufferers and which modulations are associated with tinnitus relief. In the present study we examined the effects of five different stimulation protocols (including sham) by measuring tinnitus loudness and tinnitus-related brain activity with Magnetoencephalography before and after rTMS. Changes in oscillatory activity were analysed for the stimulated auditory cortex as well as for the entire brain regarding certain frequency bands of interest (delta, theta, alpha, gamma). In line with the literature the effects of rTMS on tinnitus loudness varied strongly across patients. This variability was also reflected in the rTMS effects on oscillatory activity. Importantly, strong reductions in tinnitus loudness were associated with increases in alpha power in the stimulated auditory cortex, while an unspecific decrease in gamma and alpha power, particularly in left frontal regions, was linked to an increase in tinnitus loudness. The identification of alpha power increase as main correlate for tinnitus reduction sheds further light on the pathophysiology of tinnitus. This will hopefully stimulate the development of more effective therapy approaches.

Subject (DDC)

150 Psychology

Cite This

ISO 690

MÜLLER, Nadia, Isabel LORENZ, Berthold LANGGUTH, Nathan WEISZ, 2013. rTMS Induced Tinnitus Relief Is Related to an Increase in Auditory Cortical Alpha Activity. In: PLoS one. 8(2), e55557. eISSN 1932-6203. Available under: doi: 10.1371/journal.pone.0055557

BibTex

@article{Muller2013Induc-42261,
  year={2013},
  doi={10.1371/journal.pone.0055557},
  title={rTMS Induced Tinnitus Relief Is Related to an Increase in Auditory Cortical Alpha Activity},
  number={2},
  volume={8},
  journal={PLoS one},
  author={Müller, Nadia and Lorenz, Isabel and Langguth, Berthold and Weisz, Nathan},
  note={Article Number: e55557}
}

RDF

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/42261">
    <dc:contributor>Müller, Nadia</dc:contributor>
    <dc:creator>Müller, Nadia</dc:creator>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/42261"/>
    <dc:contributor>Weisz, Nathan</dc:contributor>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/42261/1/Mueller_2-3anhk4jf3ew09.pdf"/>
    <dc:language>eng</dc:language>
    <dcterms:abstract xml:lang="eng">Chronic tinnitus, the continuous perception of a phantom sound, is a highly prevalent audiological symptom. A promising approach for the treatment of tinnitus is repetitive transcranial magnetic stimulation (rTMS) as this directly affects tinnitus-related brain activity. Several studies indeed show tinnitus relief after rTMS, however effects are moderate and vary strongly across patients. This may be due to a lack of knowledge regarding how rTMS affects oscillatory activity in tinnitus sufferers and which modulations are associated with tinnitus relief. In the present study we examined the effects of five different stimulation protocols (including sham) by measuring tinnitus loudness and tinnitus-related brain activity with Magnetoencephalography before and after rTMS. Changes in oscillatory activity were analysed for the stimulated auditory cortex as well as for the entire brain regarding certain frequency bands of interest (delta, theta, alpha, gamma). In line with the literature the effects of rTMS on tinnitus loudness varied strongly across patients. This variability was also reflected in the rTMS effects on oscillatory activity. Importantly, strong reductions in tinnitus loudness were associated with increases in alpha power in the stimulated auditory cortex, while an unspecific decrease in gamma and alpha power, particularly in left frontal regions, was linked to an increase in tinnitus loudness. The identification of alpha power increase as main correlate for tinnitus reduction sheds further light on the pathophysiology of tinnitus. This will hopefully stimulate the development of more effective therapy approaches.</dcterms:abstract>
    <dc:contributor>Lorenz, Isabel</dc:contributor>
    <dc:creator>Lorenz, Isabel</dc:creator>
    <dcterms:title>rTMS Induced Tinnitus Relief Is Related to an Increase in Auditory Cortical Alpha Activity</dcterms:title>
    <dc:creator>Weisz, Nathan</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-05-08T11:41:28Z</dcterms:available>
    <dc:creator>Langguth, Berthold</dc:creator>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-05-08T11:41:28Z</dc:date>
    <dcterms:issued>2013</dcterms:issued>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
    <dc:contributor>Langguth, Berthold</dc:contributor>
    <dc:rights>terms-of-use</dc:rights>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/42261/1/Mueller_2-3anhk4jf3ew09.pdf"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/52"/>
  </rdf:Description>
</rdf:RDF>

Bibliography of Konstanz

No