Nodal and BMP dispersal during early zebrafish development

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2019
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Rogers, Katherine W.
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Developmental Biology. Elsevier. 2019, 447(1), pp. 14-23. ISSN 0012-1606. eISSN 1095-564X. Available under: doi: 10.1016/j.ydbio.2018.04.002
Zusammenfassung

The secreted TGF-β superfamily signals Nodal and BMP coordinate the patterning of vertebrate embryos. Nodal specifies endoderm and mesoderm during germ layer formation, and BMP specifies ventral fates and patterns the dorsal/ventral axis. Five major models have been proposed to explain how the correct distributions of Nodal and BMP are achieved within tissues to orchestrate embryogenesis: source/sink, transcriptional determination, relay, self-regulation, and shuttling. Here, we discuss recent experiments probing these signal dispersal models, focusing on early zebrafish development.

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570 Biowissenschaften, Biologie
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ISO 690ROGERS, Katherine W., Patrick MÜLLER, 2019. Nodal and BMP dispersal during early zebrafish development. In: Developmental Biology. Elsevier. 2019, 447(1), pp. 14-23. ISSN 0012-1606. eISSN 1095-564X. Available under: doi: 10.1016/j.ydbio.2018.04.002
BibTex
@article{Rogers2019Nodal-55565,
  year={2019},
  doi={10.1016/j.ydbio.2018.04.002},
  title={Nodal and BMP dispersal during early zebrafish development},
  number={1},
  volume={447},
  issn={0012-1606},
  journal={Developmental Biology},
  pages={14--23},
  author={Rogers, Katherine W. and Müller, Patrick}
}
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