@article{Kuraku2010-05-01Evolu-51573,
  year={2010},
  doi={10.1016/j.ydbio.2010.02.013},
  title={Evolution of oropharyngeal patterning mechanisms involving Dlx and endothelins in vertebrates},
  number={1},
  volume={341},
  issn={0012-1606},
  journal={Developmental Biology},
  pages={315--323},
  author={Kuraku, Shigehiro and Takio, Yoko and Sugahara, Fumiaki and Takechi, Masaki and Kuratani, Shigeru}
}

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    <dcterms:abstract xml:lang="eng">In jawed vertebrates, the Dlx code, or nested expression patterns of Dlx genes, specify the dorsoventral polarity of pharyngeal arches, downstream of endothelin-1 (Edn-1) and its effectors, Bapx1 (Nkx3.2) and dHand (Hand2). To elucidate the evolution of the specification mechanism of the oropharyngeal skeletal system, lamprey homologs of Dlx, Edn, endothelin receptor (Ednr), Bapx1, and dHand were identified. Our analysis suggested that the Edn gene family emerged at the advent of vertebrates, and that gene duplications leading to the different Edn gnathostome subtypes (Edn1–3) occurred before the cyclostome–gnathostome split. This timing of gene duplications, giving rise to multiple subtypes, was also implied for Dlx, Ednr, Hand, and Bapx. In lamprey embryos, nested expressions of Dlx genes were not observed in pharyngeal arches, nor was any focal expression of Bapx1, known in gnathostomes to specify the jaw joint. The dHand homolog, however, was expressed more intensively ventrally, as in gnathostomes. Lamprey homologs of Edn-1 and EdnrA were also shown to be expressed as described in mice, indicating involvement of this signaling pathway in the craniofacial patterning early in vertebrate evolution. These results suggest that the last common ancestor of all the extant vertebrates would have possessed basic gene repertoires involved in oropharyngeal patterning in gnathostomes, but the elaborate genetic program leading to the Dlx code is likely to have been acquired uniquely in gnathostomes.</dcterms:abstract>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-10-30T10:05:58Z</dc:date>
    <dc:contributor>Takechi, Masaki</dc:contributor>
    <dc:language>eng</dc:language>
    <dc:contributor>Sugahara, Fumiaki</dc:contributor>
    <dc:creator>Takechi, Masaki</dc:creator>
    <dc:contributor>Takio, Yoko</dc:contributor>
    <dc:creator>Kuratani, Shigeru</dc:creator>
    <dc:contributor>Kuraku, Shigehiro</dc:contributor>
    <dc:creator>Kuraku, Shigehiro</dc:creator>
    <dcterms:title>Evolution of oropharyngeal patterning mechanisms involving Dlx and endothelins in vertebrates</dcterms:title>
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    <dc:creator>Takio, Yoko</dc:creator>
    <dc:contributor>Kuratani, Shigeru</dc:contributor>
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    <dc:creator>Sugahara, Fumiaki</dc:creator>
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