Dose shift effects on an apomorphine-elicited response

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2000
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Godoy, Adriana
Siemann, Martina
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Apomorphine (Apo) a dopaminergic agonist, elicited protracted bouts of pecking when injected intramuscularly into pigeons. Repeated injections of either a small or a large dose of Apo into two separate groups of pigeons led to progressive increments in pecking up to two different asymptotic response levels (dose-related sensitization). A subsequent switch of the Apo doses between the groups yielded two statistically undistinguishable asymptotic response levels. A smaller dose of Apo induced a significantly higher asymptotic response if the pigeons pre-treated with a larger dose than if they had not. The results are discussed in relation to a simple classical conditioning model of sensitization, and are related to behavioural contrast phenomena that occur in conventional conditioning paradigms involving changes of food reward magnitudes.

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150 Psychologie
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ISO 690DELIUS, Juan, Adriana GODOY, Martina SIEMANN, 2000. Dose shift effects on an apomorphine-elicited response. In: Medical Science Research. 2000, 28, pp. 39-42. ISSN 0269-8951
BibTex
@article{Delius2000shift-20681,
  year={2000},
  title={Dose shift effects on an apomorphine-elicited response},
  volume={28},
  issn={0269-8951},
  journal={Medical Science Research},
  pages={39--42},
  author={Delius, Juan and Godoy, Adriana and Siemann, Martina}
}
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