Dose shift effects on an apomorphine-elicited response

Delius, Juan; Godoy, Adriana; Siemann, Martina

Dose shift effects on an apomorphine-elicited response

Files

Dose shift effects on an apomorphine-elicited response.pdf(763.36 KB)

Date

2000

Authors

Delius, Juan

Godoy, Adriana

Siemann, Martina

Publication type

Journal article

Published in

Medical Science Research ; 28 (2000). - pp. 39-42. - ISSN 0269-8951

Abstract

Apomorphine (Apo) a dopaminergic agonist, elicited protracted bouts of pecking when injected intramuscularly into pigeons. Repeated injections of either a small or a large dose of Apo into two separate groups of pigeons led to progressive increments in pecking up to two different asymptotic response levels (dose-related sensitization). A subsequent switch of the Apo doses between the groups yielded two statistically undistinguishable asymptotic response levels. A smaller dose of Apo induced a significantly higher asymptotic response if the pigeons pre-treated with a larger dose than if they had not. The results are discussed in relation to a simple classical conditioning model of sensitization, and are related to behavioural contrast phenomena that occur in conventional conditioning paradigms involving changes of food reward magnitudes.

Subject (DDC)

150 Psychology

Cite This

ISO 690

DELIUS, Juan, Adriana GODOY, Martina SIEMANN, 2000. Dose shift effects on an apomorphine-elicited response. In: Medical Science Research. 28, pp. 39-42. ISSN 0269-8951

BibTex

@article{Delius2000shift-20681,
  year={2000},
  title={Dose shift effects on an apomorphine-elicited response},
  volume={28},
  issn={0269-8951},
  journal={Medical Science Research},
  pages={39--42},
  author={Delius, Juan and Godoy, Adriana and Siemann, Martina}
}

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