@article{Ren2022-04-01hippo-56575,
  year={2022},
  doi={10.1097/PSY.0000000000001058},
  title={The hippocampal-ventral medial prefrontal cortex neurocircuitry involvement in the association of daily life stress with acute perceived stress and cortisol responses},
  number={3},
  volume={84},
  issn={0033-3174},
  journal={Psychosomatic medicine},
  author={Ren, Xi and Zhao, Xiaolin and Li, Jiwen and Liu, Yadong and Ren, Yipeng and Pruessner, Jens C. and Yang, Juan}
}

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    <dc:contributor>Liu, Yadong</dc:contributor>
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    <dcterms:title>The hippocampal-ventral medial prefrontal cortex neurocircuitry involvement in the association of daily life stress with acute perceived stress and cortisol responses</dcterms:title>
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    <dc:creator>Ren, Xi</dc:creator>
    <dcterms:issued>2022-04-01</dcterms:issued>
    <dc:creator>Yang, Juan</dc:creator>
    <dc:contributor>Zhao, Xiaolin</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-02-15T15:35:52Z</dc:date>
    <dc:creator>Liu, Yadong</dc:creator>
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    <dc:contributor>Pruessner, Jens C.</dc:contributor>
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    <dc:creator>Zhao, Xiaolin</dc:creator>
    <dc:creator>Ren, Yipeng</dc:creator>
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    <dc:contributor>Ren, Yipeng</dc:contributor>
    <dc:contributor>Ren, Xi</dc:contributor>
    <dc:contributor>Li, Jiwen</dc:contributor>
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    <dcterms:abstract xml:lang="eng">Objective:&lt;br /&gt;Daily life stressors include everyday irritants, hassles, and inconveniences, such as problems in traffic, and unexpected work deadlines. A growing body of research has suggested higher daily stress is associated with blunted cortisol response to acute psychosocial stressors. However, so far, the neural mechanism underlying this association has not been elucidated. The current study aimed to examine the role of stress neurocircuitry between hippocampus and ventral medial prefrontal cortex, in this relationship.&lt;br /&gt;&lt;br /&gt;Methods:&lt;br /&gt;To this end, as an index of daily stress in 44 young healthy individuals (23 females; mean age ± SD = 19.07 ± 1.11 years), the total stressful rating score of daily life stress events that occurred in a 24-hour period was quantified. Individuals were then administered a modified-versions of Montreal Imaging Stress Task (MIST) while undergoing functional magnetic resonance imaging (fMRI) scans, and their saliva samples were collected for assessment of the stress hormone cortisol.&lt;br /&gt;&lt;br /&gt;Results:&lt;br /&gt;Results revealed that a higher level of daily stress was associated with lower salivary cortisol secretion (r = -0.39, p = 0.008) and lower activation of the left hippocampus (tpeak = -5.51) in response to the MIST. Further, a higher level of daily stress was associated with stronger functional connectivity between the left hippocampus and the ventral medial prefrontal cortex/subgenual anterior cingulate cortex (tpeak = 4.91, R2 = 0.365).&lt;br /&gt;&lt;br /&gt;Conclusions:&lt;br /&gt;Taken together, the current study suggested a possible neurocircuitry of hippocampus and ventral medial prefrontal cortex, in the relationship between daily life stress and acute psychosocial stress.</dcterms:abstract>
    <dc:creator>Pruessner, Jens C.</dc:creator>
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