Publikation:

Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts

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Tournebize_140552.pdf
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Datum

2000

Autor:innen

Tournebize, Régis
Popov, Andrei
Kinoshita, Kazuhisa
Ashford, Anthony J.
Rybina, Sonja
Pozniakovsky, Andrei
Walczak, Claire E.
Karsenti, Eric
Hyman, Anthony A.

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URI (zitierfähiger Link)
http://nbn-resolving.de/urn:nbn:de:bsz:352-140552
DOI (zitierfähiger Link)
https://doi.org/10.1038/71330
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Open Access-Veröffentlichung
Open Access Green

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Biologie: Publikationen
Core Facility der Universität Konstanz

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Zeitschriftenartikel
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Published

Erschienen in

Nature Cell Biology. 2000, 2(1), pp. 13-19. ISSN 1465-7392. Available under: doi: 10.1038/71330

Zusammenfassung

Microtubules are dynamic polymers that move stochastically between periods of growth and shrinkage, a property known as dynamic instability. Here, to investigate the mechanisms regulating microtubule dynamics in Xenopus egg extracts, we have cloned the complementary DNA encoding the microtubule-associated protein XMAP215 and investigated the function of the XMAP215 protein. Immunodepletion of XMAP215 indicated that it is a major microtubule-stabilizing factor in Xenopus egg extracts. During interphase, XMAP215 stabilizes microtubules primarily by opposing the activity of the destabilizing factor XKCM1, a member of the kinesin superfamily. These results indicate that microtubule dynamics in Xenopus egg extracts are regulated by a balance between a stabilizing factor, XMAP215, and a destabilizing factor, XKCM1.

Zusammenfassung in einer weiteren Sprache

Fachgebiet (DDC)
570 Biowissenschaften, Biologie

Schlagwörter

MCAK, XMAP215, microtubule dynamics, Mitose, Chromosomenbande, Zellteilung, Mikrotubuli, Kinesin

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ISO 690TOURNEBIZE, Régis, Andrei POPOV, Kazuhisa KINOSHITA, Anthony J. ASHFORD, Sonja RYBINA, Andrei POZNIAKOVSKY, Thomas U. MAYER, Claire E. WALCZAK, Eric KARSENTI, Anthony A. HYMAN, 2000. Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts. In: Nature Cell Biology. 2000, 2(1), pp. 13-19. ISSN 1465-7392. Available under: doi: 10.1038/71330
BibTex
@article{Tournebize2000-01Contr-14055,
  year={2000},
  doi={10.1038/71330},
  title={Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts},
  number={1},
  volume={2},
  issn={1465-7392},
  journal={Nature Cell Biology},
  pages={13--19},
  author={Tournebize, Régis and Popov, Andrei and Kinoshita, Kazuhisa and Ashford, Anthony J. and Rybina, Sonja and Pozniakovsky, Andrei and Mayer, Thomas U. and Walczak, Claire E. and Karsenti, Eric and Hyman, Anthony A.}
}
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