Hindbrain patterning revisited : timing and effects of retinoic acid signalling

Begemann, Gerrit; Meyer, Axel

Hindbrain patterning revisited : timing and effects of retinoic acid signalling

Dateien

Hindbrain_patterning_revisited_timing.pdfGröße: 171.5 KBDownloads: 396

Datum

2001

Open Access-Veröffentlichung

Open Access Green

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

BioEssays. 2001, 23(11), pp. 981-986. ISSN 0265-9247. eISSN 1521-1878. Available under: doi: 10.1002/bies.1142

Zusammenfassung

Retinoids play a critical role in patterning, segmentation, and neurogenesis of the posterior hindbrain and it has been proposed that they act as a posteriorising signal during hindbrain development. Until now, direct evidence that endogenous retinoid signalling acts through a gradient to specify cell fates along the anteroposterior axis has been missing. Two recent studies tested the requirement for retinoid signalling in the developing hindbrain through systematic application of a panretinoic acid receptor antagonist.(1,2) They demonstrate a stage-dependent requirement for increasing retinoid signalling activity along the hindbrain that proceeds from anterior to posterior. Together these findings challenge the concept of a stable gradient of retinoic acid across the hindbrain and warrant a re-interpretation of the phenotypes obtained by genetic and nutritional disruption of retinoid signalling in the amniote embryo.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

BEGEMANN, Gerrit, Axel MEYER, 2001. Hindbrain patterning revisited : timing and effects of retinoic acid signalling. In: BioEssays. 2001, 23(11), pp. 981-986. ISSN 0265-9247. eISSN 1521-1878. Available under: doi: 10.1002/bies.1142

BibTex

@article{Begemann2001Hindb-7694,
  year={2001},
  doi={10.1002/bies.1142},
  title={Hindbrain patterning revisited : timing and effects of retinoic acid signalling},
  number={11},
  volume={23},
  issn={0265-9247},
  journal={BioEssays},
  pages={981--986},
  author={Begemann, Gerrit and Meyer, Axel}
}

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