Publikation: Hindbrain patterning revisited : timing and effects of retinoic acid signalling
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2001
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BioEssays. 2001, 23(11), pp. 981-986. ISSN 0265-9247. eISSN 1521-1878. Available under: doi: 10.1002/bies.1142
Zusammenfassung
Retinoids play a critical role in patterning, segmentation, and neurogenesis of the posterior hindbrain and it has been proposed that they act as a posteriorising signal during hindbrain development. Until now, direct evidence that endogenous retinoid signalling acts through a gradient to specify cell fates along the anteroposterior axis has been missing. Two recent studies tested the requirement for retinoid signalling in the developing hindbrain through systematic application of a panretinoic acid receptor antagonist.(1,2) They demonstrate a stage-dependent requirement for increasing retinoid signalling activity along the hindbrain that proceeds from anterior to posterior. Together these findings challenge the concept of a stable gradient of retinoic acid across the hindbrain and warrant a re-interpretation of the phenotypes obtained by genetic and nutritional disruption of retinoid signalling in the amniote embryo.
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570 Biowissenschaften, Biologie
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BEGEMANN, Gerrit, Axel MEYER, 2001. Hindbrain patterning revisited : timing and effects of retinoic acid signalling. In: BioEssays. 2001, 23(11), pp. 981-986. ISSN 0265-9247. eISSN 1521-1878. Available under: doi: 10.1002/bies.1142BibTex
@article{Begemann2001Hindb-7694,
year={2001},
doi={10.1002/bies.1142},
title={Hindbrain patterning revisited : timing and effects of retinoic acid signalling},
number={11},
volume={23},
issn={0265-9247},
journal={BioEssays},
pages={981--986},
author={Begemann, Gerrit and Meyer, Axel}
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<dcterms:abstract xml:lang="eng">Retinoids play a critical role in patterning, segmentation, and neurogenesis of the posterior hindbrain and it has been proposed that they act as a posteriorising signal during hindbrain development. Until now, direct evidence that endogenous retinoid signalling acts through a gradient to specify cell fates along the anteroposterior axis has been missing. Two recent studies tested the requirement for retinoid signalling in the developing hindbrain through systematic application of a panretinoic acid receptor antagonist.(1,2) They demonstrate a stage-dependent requirement for increasing retinoid signalling activity along the hindbrain that proceeds from anterior to posterior. Together these findings challenge the concept of a stable gradient of retinoic acid across the hindbrain and warrant a re-interpretation of the phenotypes obtained by genetic and nutritional disruption of retinoid signalling in the amniote embryo.</dcterms:abstract>
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