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Hindbrain patterning revisited : timing and effects of retinoic acid signalling

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Hindbrain_patterning_revisited_timing.pdf
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2001

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BioEssays. 2001, 23(11), pp. 981-986. ISSN 0265-9247. eISSN 1521-1878. Available under: doi: 10.1002/bies.1142

Zusammenfassung

Retinoids play a critical role in patterning, segmentation, and neurogenesis of the posterior hindbrain and it has been proposed that they act as a posteriorising signal during hindbrain development. Until now, direct evidence that endogenous retinoid signalling acts through a gradient to specify cell fates along the anteroposterior axis has been missing. Two recent studies tested the requirement for retinoid signalling in the developing hindbrain through systematic application of a panretinoic acid receptor antagonist.(1,2) They demonstrate a stage-dependent requirement for increasing retinoid signalling activity along the hindbrain that proceeds from anterior to posterior. Together these findings challenge the concept of a stable gradient of retinoic acid across the hindbrain and warrant a re-interpretation of the phenotypes obtained by genetic and nutritional disruption of retinoid signalling in the amniote embryo.

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570 Biowissenschaften, Biologie

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ISO 690BEGEMANN, Gerrit, Axel MEYER, 2001. Hindbrain patterning revisited : timing and effects of retinoic acid signalling. In: BioEssays. 2001, 23(11), pp. 981-986. ISSN 0265-9247. eISSN 1521-1878. Available under: doi: 10.1002/bies.1142
BibTex
@article{Begemann2001Hindb-7694,
  year={2001},
  doi={10.1002/bies.1142},
  title={Hindbrain patterning revisited : timing and effects of retinoic acid signalling},
  number={11},
  volume={23},
  issn={0265-9247},
  journal={BioEssays},
  pages={981--986},
  author={Begemann, Gerrit and Meyer, Axel}
}
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