Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice
Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice
Loading...
Date
2010
Authors
Editors
Journal ISSN
Electronic ISSN
ISBN
Bibliographical data
Publisher
Series
URI (citable link)
DOI (citable link)
International patent number
Link to the license
EU project number
Project
Open Access publication
Collections
Title in another language
Publication type
Journal article
Publication status
Published in
European Journal of Immunology ; 40 (2010), 12. - pp. 3439-3449. - ISSN 0014-2980. - eISSN 1521-4141
Abstract
Immunoproteasomes containing the IFN-inducible subunits β1i (LMP2), β2i (MECL-1) and β5i (LMP7) alter proteasomal cleavage preference and optimize the generation of peptide ligands of MHC class I molecules. Here, we report on an unexpected new function of immunoproteasome subunits for the survival and expansion of CD4+ and CD8+ T cells during viral infection of mice. The effect of immunoproteasome subunit deficiency on T-cell survival upon adoptive transfer was most prominent for the lack of LMP7 followed by MECL-1 and LMP2. The survival of T cells in uninfected mice or the homeostatic expansion after transfer into RAG-2−/− mice was not affected by the lack of the immunosubunits. Lymphocytic choriomeningitis virus (LCMV)-specific CD8+ T cells lacking LMP7 or MECL-1 started to divide after transfer into LCMV-infected mice but experienced a considerable cell loss within 2 days after transfer. We provide strong evidence that the loss of immunoproteasome-deficient T cells after transfer is not a consequence of graft rejection by the host, but instead is based on the requirement for immunoproteasomes for the survival of T cells in LCMV-infected mice. Therefore, the immunoproteasome may qualify as a potential new target for the suppression of undesired proinflammatory T-cell responses.
Summary in another language
Subject (DDC)
570 Biosciences, Biology
Keywords
Cytotoxic T lymphocytes,Immunoproteasome,LCMV,MHC class I
Conference
Review
undefined / . - undefined, undefined. - (undefined; undefined)
Cite This
ISO 690
MOEBIUS, Jacqueline, Maries van den BROEK, Marcus GRÖTTRUP, Michael BASLER, 2010. Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice. In: European Journal of Immunology. 40(12), pp. 3439-3449. ISSN 0014-2980. eISSN 1521-4141. Available under: doi: 10.1002/eji.201040620BibTex
@article{Moebius2010-12Immun-15154, year={2010}, doi={10.1002/eji.201040620}, title={Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice}, number={12}, volume={40}, issn={0014-2980}, journal={European Journal of Immunology}, pages={3439--3449}, author={Moebius, Jacqueline and Broek, Maries van den and Gröttrup, Marcus and Basler, Michael} }
RDF
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/15154"> <dc:contributor>Basler, Michael</dc:contributor> <dc:contributor>Moebius, Jacqueline</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/15154"/> <dc:creator>Broek, Maries van den</dc:creator> <dcterms:bibliographicCitation>Publ. in: European Journal of Immunology ; 40 (2010), 12. - pp. 3439-3449</dcterms:bibliographicCitation> <dcterms:title>Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice</dcterms:title> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/15154/2/Moebius_151545.pdf"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-31T06:46:06Z</dc:date> <dcterms:issued>2010-12</dcterms:issued> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/15154/2/Moebius_151545.pdf"/> <dc:contributor>Broek, Maries van den</dc:contributor> <dc:rights>terms-of-use</dc:rights> <dc:creator>Moebius, Jacqueline</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-31T06:46:06Z</dcterms:available> <dc:creator>Basler, Michael</dc:creator> <dc:creator>Gröttrup, Marcus</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/"/> <dcterms:abstract xml:lang="eng">Immunoproteasomes containing the IFN-inducible subunits β1i (LMP2), β2i (MECL-1) and β5i (LMP7) alter proteasomal cleavage preference and optimize the generation of peptide ligands of MHC class I molecules. Here, we report on an unexpected new function of immunoproteasome subunits for the survival and expansion of CD4+ and CD8+ T cells during viral infection of mice. The effect of immunoproteasome subunit deficiency on T-cell survival upon adoptive transfer was most prominent for the lack of LMP7 followed by MECL-1 and LMP2. The survival of T cells in uninfected mice or the homeostatic expansion after transfer into RAG-2−/− mice was not affected by the lack of the immunosubunits. Lymphocytic choriomeningitis virus (LCMV)-specific CD8+ T cells lacking LMP7 or MECL-1 started to divide after transfer into LCMV-infected mice but experienced a considerable cell loss within 2 days after transfer. We provide strong evidence that the loss of immunoproteasome-deficient T cells after transfer is not a consequence of graft rejection by the host, but instead is based on the requirement for immunoproteasomes for the survival of T cells in LCMV-infected mice. Therefore, the immunoproteasome may qualify as a potential new target for the suppression of undesired proinflammatory T-cell responses.</dcterms:abstract> <dc:contributor>Gröttrup, Marcus</dc:contributor> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/> <dc:language>eng</dc:language> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> </rdf:Description> </rdf:RDF>
Internal note
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Examination date of dissertation
Method of financing
Comment on publication
Alliance license
Corresponding Authors der Uni Konstanz vorhanden
International Co-Authors
Bibliography of Konstanz
Yes