@article{Moebius2010-12Immun-15154,
  year={2010},
  doi={10.1002/eji.201040620},
  title={Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice},
  number={12},
  volume={40},
  issn={0014-2980},
  journal={European Journal of Immunology},
  pages={3439--3449},
  author={Moebius, Jacqueline and Broek, Maries van den and Gröttrup, Marcus and Basler, Michael}
}

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/15154">
    <dc:contributor>Basler, Michael</dc:contributor>
    <dc:contributor>Moebius, Jacqueline</dc:contributor>
    <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/15154"/>
    <dc:creator>Broek, Maries van den</dc:creator>
    <dcterms:bibliographicCitation>Publ. in: European Journal of Immunology ; 40 (2010), 12. - pp. 3439-3449</dcterms:bibliographicCitation>
    <dcterms:title>Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice</dcterms:title>
    <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/15154/2/Moebius_151545.pdf"/>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-31T06:46:06Z</dc:date>
    <dcterms:issued>2010-12</dcterms:issued>
    <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/15154/2/Moebius_151545.pdf"/>
    <dc:contributor>Broek, Maries van den</dc:contributor>
    <dc:rights>terms-of-use</dc:rights>
    <dc:creator>Moebius, Jacqueline</dc:creator>
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-08-31T06:46:06Z</dcterms:available>
    <dc:creator>Basler, Michael</dc:creator>
    <dc:creator>Gröttrup, Marcus</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:abstract xml:lang="eng">Immunoproteasomes containing the IFN-inducible subunits β1i (LMP2), β2i (MECL-1) and β5i (LMP7) alter proteasomal cleavage preference and optimize the generation of peptide ligands of MHC class I molecules. Here, we report on an unexpected new function of immunoproteasome subunits for the survival and expansion of CD4+ and CD8+ T cells during viral infection of mice. The effect of immunoproteasome subunit deficiency on T-cell survival upon adoptive transfer was most prominent for the lack of LMP7 followed by MECL-1 and LMP2. The survival of T cells in uninfected mice or the homeostatic expansion after transfer into RAG-2−/− mice was not affected by the lack of the immunosubunits. Lymphocytic choriomeningitis virus (LCMV)-specific CD8+ T cells lacking LMP7 or MECL-1 started to divide after transfer into LCMV-infected mice but experienced a considerable cell loss within 2 days after transfer. We provide strong evidence that the loss of immunoproteasome-deficient T cells after transfer is not a consequence of graft rejection by the host, but instead is based on the requirement for immunoproteasomes for the survival of T cells in LCMV-infected mice. Therefore, the immunoproteasome may qualify as a potential new target for the suppression of undesired proinflammatory T-cell responses.</dcterms:abstract>
    <dc:contributor>Gröttrup, Marcus</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:language>eng</dc:language>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
  </rdf:Description>
</rdf:RDF>