A tree of life? : Multivariate logistic outcome-prediction in disorders of consciousness

Lade...
Vorschaubild
Dateien
Zu diesem Dokument gibt es keine Dateien.
Datum
2020
Autor:innen
Herausgeber:innen
Kontakt
ISSN der Zeitschrift
Electronic ISSN
ISBN
Bibliografische Daten
Verlag
Schriftenreihe
Auflagebezeichnung
URI (zitierfähiger Link)
ArXiv-ID
Internationale Patentnummer
Angaben zur Forschungsförderung
Projekt
Open Access-Veröffentlichung
Sammlungen
Core Facility der Universität Konstanz
Gesperrt bis
Titel in einer weiteren Sprache
Forschungsvorhaben
Organisationseinheiten
Zeitschriftenheft
Publikationstyp
Zeitschriftenartikel
Publikationsstatus
Published
Erschienen in
Zusammenfassung

Background: Clinical outcome of patients with disorders of consciousness (DOC) is seen as generally very poor. Here, we specify individual outcome chances for patients with DOC on the basis of clinical and event-related-potentials (ERPs) data and identify subgroups, who vary substantially regarding their outcome chances.

Methods: We employed data from 102 patients and used standard clinical protocol data (age, etiology, diagnosis, gender), sensory (N100, Mismatch-Negativity) and cognitive (P300, N400) ERPs to predict patients' recovery rates.

Results: Two significant prediction models emerged: In both, subgroups of patients with good (51%, tree 1) to very good recovery chances (97%, tree 2) could be identified. The first model was obtained from standard clinical data. The second model included cognitive ERPs and resulted in considerably better patient classification. Moreover, when taking cognitive ERPs into account, the standard protocol data did not add further significant information, neither did sensory ERPs.

Conclusion: The presented information about outcome chances of individual patients with DOC will be vital for these patients and critical for clinical professionals who have to direct specialized treatments and council relatives. Legal guardians and families, in turn, need to know what to expect in the future in order to prepare for the challenges ahead.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
150 Psychologie
Schlagwörter
Disorders of consciousness, unresponsive wakefulness syndrome, minimal consciousness state, logistic outcome-prediction
Konferenz
Rezension
undefined / . - undefined, undefined
Zitieren
ISO 690STEPPACHER, Inga, Peter FUCHS, Michael KAPS, Fridtjof W. NUSSBECK, Johanna KISSLER, 2020. A tree of life? : Multivariate logistic outcome-prediction in disorders of consciousness. In: Brain Injury. Taylor & Francis. 2020, 34(3), pp. 399-406. ISSN 0269-9052. eISSN 1362-301X. Available under: doi: 10.1080/02699052.2019.1695289
BibTex
@article{Steppacher2020Multi-53269,
  year={2020},
  doi={10.1080/02699052.2019.1695289},
  title={A tree of life? : Multivariate logistic outcome-prediction in disorders of consciousness},
  number={3},
  volume={34},
  issn={0269-9052},
  journal={Brain Injury},
  pages={399--406},
  author={Steppacher, Inga and Fuchs, Peter and Kaps, Michael and Nussbeck, Fridtjof W. and Kissler, Johanna}
}
RDF
<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/53269">
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-03-26T08:07:29Z</dcterms:available>
    <dc:language>eng</dc:language>
    <dc:creator>Kaps, Michael</dc:creator>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dcterms:issued>2020</dcterms:issued>
    <dc:creator>Nussbeck, Fridtjof W.</dc:creator>
    <dc:creator>Steppacher, Inga</dc:creator>
    <dc:rights>terms-of-use</dc:rights>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:contributor>Steppacher, Inga</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/43"/>
    <dc:contributor>Kaps, Michael</dc:contributor>
    <dc:contributor>Fuchs, Peter</dc:contributor>
    <dc:creator>Kissler, Johanna</dc:creator>
    <dc:contributor>Kissler, Johanna</dc:contributor>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2021-03-26T08:07:29Z</dc:date>
    <dc:creator>Fuchs, Peter</dc:creator>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dcterms:abstract xml:lang="eng">Background: Clinical outcome of patients with disorders of consciousness (DOC) is seen as generally very poor. Here, we specify individual outcome chances for patients with DOC on the basis of clinical and event-related-potentials (ERPs) data and identify subgroups, who vary substantially regarding their outcome chances.&lt;br /&gt;&lt;br /&gt;Methods: We employed data from 102 patients and used standard clinical protocol data (age, etiology, diagnosis, gender), sensory (N100, Mismatch-Negativity) and cognitive (P300, N400) ERPs to predict patients' recovery rates.&lt;br /&gt;&lt;br /&gt;Results: Two significant prediction models emerged: In both, subgroups of patients with good (51%, tree 1) to very good recovery chances (97%, tree 2) could be identified. The first model was obtained from standard clinical data. The second model included cognitive ERPs and resulted in considerably better patient classification. Moreover, when taking cognitive ERPs into account, the standard protocol data did not add further significant information, neither did sensory ERPs.&lt;br /&gt;&lt;br /&gt;Conclusion: The presented information about outcome chances of individual patients with DOC will be vital for these patients and critical for clinical professionals who have to direct specialized treatments and council relatives. Legal guardians and families, in turn, need to know what to expect in the future in order to prepare for the challenges ahead.</dcterms:abstract>
    <dc:contributor>Nussbeck, Fridtjof W.</dc:contributor>
    <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/53269"/>
    <dcterms:title>A tree of life? : Multivariate logistic outcome-prediction in disorders of consciousness</dcterms:title>
  </rdf:Description>
</rdf:RDF>
Interner Vermerk
xmlui.Submission.submit.DescribeStep.inputForms.label.kops_note_fromSubmitter
Kontakt
URL der Originalveröffentl.
Prüfdatum der URL
Prüfungsdatum der Dissertation
Finanzierungsart
Kommentar zur Publikation
Allianzlizenz
Corresponding Authors der Uni Konstanz vorhanden
Internationale Co-Autor:innen
Universitätsbibliographie
Ja
Begutachtet
Ja
Diese Publikation teilen