Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply?
Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply?
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The American Journal of Clinical Nutrition ; 62 (1995), 6. - S. 1527S-1534S. - Oxford University Press. - ISSN 0002-9165. - eISSN 1938-3207
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Previously, the metabolism of alpha-tocopherol was considered to involve the opening of the chroman structure because of its oxidation to tocopherylquinone. In contrast, we describe here 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC) as the major urinary metabolite of alpha-tocopherol that appears in human urine after vitamin E supplementation. It is formed directly from alpha-tocopherol without previous oxidative splitting of the chroman ring. The correlation of alpha-tocopherol intake, plasma alpha-tocopherol concentrations, and urinary excretion of alpha-CEHC in human volunteers supplemented with RRR-alpha-tocopherol dosages ranging from 0 to 800 mg/d was examined. HPLC and gas chromatography-mass spectroscopy analysis revealed that alpha-CEHC was only excreted when a plasma threshold of 7-9 mumol alpha-tocopherol/g total lipid was exceeded. This concentration was obtained by a daily intake of approximately 50-150 mg alpha-tocopherol. We suggest that alpha-CEHC excretion indicates a saturated binding capacity of vitamin E in the plasma and thus may be considered to be a marker of optimum vitamin E intake.
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SCHULTZ, Manfred, Marcel LEIST, M. PETRZIKA, Berthold GASSMANN, Regina BRIGELIUS-FLOHÉ, 1995. Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply?. In: The American Journal of Clinical Nutrition. Oxford University Press. 62(6), pp. 1527S-1534S. ISSN 0002-9165. eISSN 1938-3207. Available under: doi: 10.1093/ajcn/62.6.1527SBibTex
@article{Schultz1995Novel-51351, year={1995}, doi={10.1093/ajcn/62.6.1527S}, title={Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply?}, number={6}, volume={62}, issn={0002-9165}, journal={The American Journal of Clinical Nutrition}, pages={1527S--1534S}, author={Schultz, Manfred and Leist, Marcel and Petrzika, M. and Gassmann, Berthold and Brigelius-Flohé, Regina} }
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