Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply?

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1995
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Schultz, Manfred
Petrzika, M.
Gassmann, Berthold
Brigelius-Flohé, Regina
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Previously, the metabolism of alpha-tocopherol was considered to involve the opening of the chroman structure because of its oxidation to tocopherylquinone. In contrast, we describe here 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC) as the major urinary metabolite of alpha-tocopherol that appears in human urine after vitamin E supplementation. It is formed directly from alpha-tocopherol without previous oxidative splitting of the chroman ring. The correlation of alpha-tocopherol intake, plasma alpha-tocopherol concentrations, and urinary excretion of alpha-CEHC in human volunteers supplemented with RRR-alpha-tocopherol dosages ranging from 0 to 800 mg/d was examined. HPLC and gas chromatography-mass spectroscopy analysis revealed that alpha-CEHC was only excreted when a plasma threshold of 7-9 mumol alpha-tocopherol/g total lipid was exceeded. This concentration was obtained by a daily intake of approximately 50-150 mg alpha-tocopherol. We suggest that alpha-CEHC excretion indicates a saturated binding capacity of vitamin E in the plasma and thus may be considered to be a marker of optimum vitamin E intake.

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ISO 690SCHULTZ, Manfred, Marcel LEIST, M. PETRZIKA, Berthold GASSMANN, Regina BRIGELIUS-FLOHÉ, 1995. Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply?. In: The American Journal of Clinical Nutrition. Oxford University Press. 1995, 62(6), pp. 1527S-1534S. ISSN 0002-9165. eISSN 1938-3207. Available under: doi: 10.1093/ajcn/62.6.1527S
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@article{Schultz1995Novel-51351,
  year={1995},
  doi={10.1093/ajcn/62.6.1527S},
  title={Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply?},
  number={6},
  volume={62},
  issn={0002-9165},
  journal={The American Journal of Clinical Nutrition},
  pages={1527S--1534S},
  author={Schultz, Manfred and Leist, Marcel and Petrzika, M. and Gassmann, Berthold and Brigelius-Flohé, Regina}
}
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