Schreiber, Falk

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Towards systems biology of developing barley grains : a framework for modeling metabolism

2008, Grafahrend-Belau, Eva, Junker, Björn H., Koschützki, Dirk, Klukas, Christian, Weise, Stephan, Scholz, Uwe, Schreiber, Falk

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Meta-All : a system for managing metabolic pathway information

2006, Weise, Stephan, Grosse, Ivo, Klukas, Christian, Koschützki, Dirk, Scholz, Uwe, Schreiber, Falk, Junker, Björn H.

Background

Many attempts are being made to understand biological subjects at a systems level. A major resource for these approaches are biological databases, storing manifold information about DNA, RNA and protein sequences including their functional and structural motifs, molecular markers, mRNA expression levels, metabolite concentrations, protein-protein interactions, phenotypic traits or taxonomic relationships. The use of these databases is often hampered by the fact that they are designed for special application areas and thus lack universality. Databases on metabolic pathways, which provide an increasingly important foundation for many analyses of biochemical processes at a systems level, are no exception from the rule. Data stored in central databases such as KEGG, BRENDA or SABIO-RK is often limited to read-only access. If experimentalists want to store their own data, possibly still under investigation, there are two possibilities. They can either develop their own information system for managing that own data, which is very time-consuming and costly, or they can try to store their data in existing systems, which is often restricted. Hence, an out-of-the-box information system for managing metabolic pathway data is needed.

Results

We have designed META-ALL, an information system that allows the management of metabolic pathways, including reaction kinetics, detailed locations, environmental factors and taxonomic information. Data can be stored together with quality tags and in different parallel versions. META-ALL uses Oracle DBMS and Oracle Application Express. We provide the META-ALL information system for download and use. In this paper, we describe the database structure and give information about the tools for submitting and accessing the data. As a first application of META-ALL, we show how the information contained in a detailed kinetic model can be stored and accessed.

Conclusion

META-ALL is a system for managing information about metabolic pathways. It facilitates the handling of pathway-related data and is designed to help biochemists and molecular biologists in their daily research. It is available on the Web at http://bic-gh.de/meta-all and can be downloaded free of charge and installed locally.

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Kinetic Modelling with the Systems Biology Modelling Environment SyBME

2006, Junker, Björn H., Koschützki, Dirk, Schreiber, Falk

Kinetic modelling and simulation is an important approach in systems biology. While the focus of current modelling tools is on simulation, model development is a highly iterative process which is currently only partly supported. To support the development of biochemical models, their simulation, and graphical understanding, we designed and implemented SyBME, the Systems Biology Modelling Environment. Here we present the architecture and the main components of SyBME and show its use by modelling sucrose breakdown in developing potato tubers.