Presentation of lipoteichoic acid potentiates its inflammatory activity

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DEININGER, Susanne, Stephanie TRAUB, Diana AICHELE, Tamara RUPP, Teodora BARIS, Heiko M. MÖLLER, Thomas HARTUNG, Sonja von AULOCK, 2008. Presentation of lipoteichoic acid potentiates its inflammatory activity. In: Immunobiology. 213(6), pp. 519-529. ISSN 0171-2985. Available under: doi: 10.1016/j.imbio.2008.01.001

@article{Deininger2008Prese-9714, title={Presentation of lipoteichoic acid potentiates its inflammatory activity}, year={2008}, doi={10.1016/j.imbio.2008.01.001}, number={6}, volume={213}, issn={0171-2985}, journal={Immunobiology}, pages={519--529}, author={Deininger, Susanne and Traub, Stephanie and Aichele, Diana and Rupp, Tamara and Baris, Teodora and Möller, Heiko M. and Hartung, Thomas and Aulock, Sonja von} }

Hartung, Thomas Möller, Heiko M. Lipoteichoic acid (LTA) is a major immunostimulatory molecule in the cell wall of Gram-positive bacteria. Adhesion of LTA to a polystyrene surface drastically increased its immunostimulatory potency in human whole blood in comparison to soluble LTA, although only 1% of the LTA had bound, as determined using rhodamine-labelled LTA. The release of the proinflammatory cytokines IL-1beta, TNF and IL-6 and the chemokines IL-8 and G-CSF was increased 2- to 10-fold, but IL-10 release was unaltered. This presentation effect was not shared by lipopolysaccharide (LPS) or other toll-like receptor 2 agonists and was less pronounced in polypropylene vessels. LTA did not induce cytokine release in silicone-coated borosilicate vessels, but covalent coupling of LTA to polystyrene beads restored cytokine induction in these vessels, indicating that presentation of LTA on a surface is in fact essential for its immunostimulatory potency.<br />This novel aspect of presentation as a factor in the recognition of LTA may reflect the physiological situation in the bacterial cell wall, where LTA is anchored in the bacterial membrane and projects through the peptidoglycan. In practical terms, contamination of medical devices with components of Gram-positive bacteria may pose an underestimated inflammatory risk. 2008 Aulock, Sonja von Traub, Stephanie Baris, Teodora eng terms-of-use Baris, Teodora First publ. in: Immunobiology 213 (2008), 6, pp. 519 529 Rupp, Tamara Rupp, Tamara 2011-03-24T18:13:54Z Deininger, Susanne 2011-03-24T18:13:54Z Traub, Stephanie Aichele, Diana Presentation of lipoteichoic acid potentiates its inflammatory activity Hartung, Thomas Aichele, Diana Deininger, Susanne application/pdf Aulock, Sonja von Möller, Heiko M.

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