Type of Publication: | Journal article |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-108412 |
Author: | Mezö, Gábor; Manea, Marilena |
Year of publication: | 2009 |
Published in: | Expert Opinion On Therapeutics Patents ; 19 (2009), 12. - pp. 1771-1785. - ISSN 1354-3776. - eISSN 1744-7674 |
Pubmed ID: | 19939192 |
DOI (citable link): | https://dx.doi.org/10.1517/13543770903410237 |
Summary: |
Luteinizing hormone-releasing hormone (LH-RH) plays a central role in the vertebrate reproduction by regulating gonadal activity. Based on its binding to pituitary LH-RH receptors, as well as to LH-RH receptors expressed on cancer cells, LH-RH agonists and antagonists have been developed for different therapeutic applications.
Objective/method: Here we give an overview of the most relevant LH-RH antagonists and their therapeutic applications. Recently patented compounds as well as drug formulations and dosage are presented. Conclusion: LH-RH antagonists have found clinical applications in in vitro fertilization, benign prostatic hyperplasia, endometriosis and in the treatment of hormone-dependent tumors. Work in progress is focused on further development of both peptidic and orally active non-peptidic LH-RH antagonists. |
Subject (DDC): | 540 Chemistry |
Link to License: | In Copyright |
Bibliography of Konstanz: | Yes |
MEZÖ, Gábor, Marilena MANEA, 2009. Luteinizing hormone-releasing hormone antagonists. In: Expert Opinion On Therapeutics Patents. 19(12), pp. 1771-1785. ISSN 1354-3776. eISSN 1744-7674. Available under: doi: 10.1517/13543770903410237
@article{Mezo2009Lutei-9668, title={Luteinizing hormone-releasing hormone antagonists}, year={2009}, doi={10.1517/13543770903410237}, number={12}, volume={19}, issn={1354-3776}, journal={Expert Opinion On Therapeutics Patents}, pages={1771--1785}, author={Mezö, Gábor and Manea, Marilena} }
Mezo_EOTP_2009.pdf | 396 |