KOPS - The Institutional Repository of the University of Konstanz

The reconstitution of immunocompetence by GM-CSF or IFN[gamma] after pharmacological suppression

The reconstitution of immunocompetence by GM-CSF or IFN[gamma] after pharmacological suppression

Cite This

Files in this item

Checksum: MD5:393670d6bc6547eb29554305bc4d65db

KÜHNLE, Simone, 2000. The reconstitution of immunocompetence by GM-CSF or IFN[gamma] after pharmacological suppression [Dissertation]. Konstanz: University of Konstanz

@phdthesis{Kuhnle2000recon-7684, title={The reconstitution of immunocompetence by GM-CSF or IFN[gamma] after pharmacological suppression}, year={2000}, author={Kühnle, Simone}, address={Konstanz}, school={Universität Konstanz} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7684"> <dc:format>application/pdf</dc:format> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:rights>terms-of-use</dc:rights> <dc:language>deu</dc:language> <dc:creator>Kühnle, Simone</dc:creator> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dcterms:title>The reconstitution of immunocompetence by GM-CSF or IFN[gamma] after pharmacological suppression</dcterms:title> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7684"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:21Z</dcterms:available> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7684/1/kuehnle.pdf"/> <dcterms:abstract xml:lang="eng">While immunosuppression is required to prevent graft rejection in transplantation, it increases the risk of infection. We investigated in mice immunosuppressed by different immunosuppressives (cyclosporin A, dexamethasone, tacrolimus and sirolimus), whether the innate immune system can be reactivated by granulocyte-macrophage colony stimulating factor (GM-CSF) or interferon-gamma (IFNg). Both study drugs reconstituted the suppressed macrophage response ex vivo and in vivo, while the IL-2 and IFNg response of T-cells remained silenced. Mice, immunosuppressed by cyclosporin A or dexamethasone survived a lethal Salmonella typhimurium infection when pretreated with GM-CSF or IFNg without inducing skin graft rejection after allotransplantation. We propose to consider GM-CSF or IFNg for a therapeutic improvement of the resistance of transplant patients to infections.</dcterms:abstract> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7684/1/kuehnle.pdf"/> <dcterms:issued>2000</dcterms:issued> <dc:contributor>Kühnle, Simone</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:21Z</dc:date> </rdf:Description> </rdf:RDF>

Downloads since Oct 1, 2014 (Information about access statistics)

kuehnle.pdf 177

This item appears in the following Collection(s)

Search KOPS


Browse

My Account