Type of Publication: | Journal article |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-48399 |
Author: | Bastmeyer, Martin; Jeserich, Gunnar; Stürmer, Claudia |
Year of publication: | 1994 |
Published in: | Glia ; 11 (1994), 4. - pp. 300-314. - ISSN 0894-1491. - eISSN 1098-1136 |
DOI (citable link): | https://dx.doi.org/10.1002/glia.440110403 |
Summary: |
n light of the striking differences between oligodendrocytes of the optic nerve/tract of adult goldfish and their mammalian counterparts, a further characterization of goldfish oligodendrocytes was performed. A comparison with Schwann cells was included because fish optic nerve/tract-derived oligodendrocytes bear remarkable similarities to this type of glial cell. Fish optic nerve/tract-derived oligodendrocytes that had differentiated into 04 and 6D2-positive cells and thus expressed early myelin marker molecules were found to incorporate BrdU and to divide in vitro over a period of weeks. For the induction of more advanced markers of myelinogenesis such as the CNS-specific myelin protein 36K, oligodendrocytes required extensive contact with axons. Other agents, such as fetal calf or carp serum, substrate components, or forscolin failed, however, to induce 36K expression. 04/6D2-positive oligodendrocytes could be distinguished from fish 6D2-positive Schwann cells derived from cranial nerves by their antigenic pheno-type: Schwann cells but not oligodendrocytes exhibited the low affinity NGF receptor. While both cell types carry the cell adhesion molecules NCAM, E 587 antigen, and the L2/HNK-1 epitope, only Schwann cells possess a further adhesion molecule, Neurolin.
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Subject (DDC): | 570 Biosciences, Biology |
Keywords: | Goldfish, Optic nerve/tract, Cranial nerves, Myelin proteins, NGF-receptor, Cell adhesion molecules |
Link to License: | Attribution-NonCommercial-NoDerivs 2.0 Generic |
BASTMEYER, Martin, Gunnar JESERICH, Claudia STÜRMER, 1994. Similarities and differences between fish oligodendrocytes and schwann cells in vitro. In: Glia. 11(4), pp. 300-314. ISSN 0894-1491. eISSN 1098-1136. Available under: doi: 10.1002/glia.440110403
@article{Bastmeyer1994Simil-7350, title={Similarities and differences between fish oligodendrocytes and schwann cells in vitro}, year={1994}, doi={10.1002/glia.440110403}, number={4}, volume={11}, issn={0894-1491}, journal={Glia}, pages={300--314}, author={Bastmeyer, Martin and Jeserich, Gunnar and Stürmer, Claudia} }
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Similarities_and_differences_between_fish_oligodendrocytes_and_schwann_cells_in_vitro.pdf | 748 |