Membrane elastic fluctuations and the insertion and tilt of beta-barrel proteins


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MARSH, Derek, Baladhandapani SHANMUGAVADIVU, Jörg H. KLEINSCHMIDT, 2006. Membrane elastic fluctuations and the insertion and tilt of beta-barrel proteins. In: Biophysical Journal. 91(1), pp. 227-232. ISSN 0006-3495. Available under: doi: 10.1529/biophysj.105.079004

@article{Marsh2006Membr-7138, title={Membrane elastic fluctuations and the insertion and tilt of beta-barrel proteins}, year={2006}, doi={10.1529/biophysj.105.079004}, number={1}, volume={91}, issn={0006-3495}, journal={Biophysical Journal}, pages={227--232}, author={Marsh, Derek and Shanmugavadivu, Baladhandapani and Kleinschmidt, Jörg H.} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:language>eng</dc:language> <dcterms:available rdf:datatype="">2011-03-24T17:32:09Z</dcterms:available> <dc:rights>terms-of-use</dc:rights> <dc:contributor>Shanmugavadivu, Baladhandapani</dc:contributor> <dcterms:abstract xml:lang="eng">Folding of porin-like β-barrel outer membrane proteins can be achieved in the presence of phospholipid vesicles, and takes place concurrently with incorporation into the membrane. The pronounced dependence found for the insertion of the protein OmpA on membrane thickness (Kleinschmidt, J. H., and L. K. Tamm. 2002. J. Mol. Biol. 324:319 330) is analyzed interms of the effects of out-of-plane elastic fluctuations on the area dilation modulus (Evans, E., and W. Rawicz. 1990. Phys. Rev. Lett. 64:2094 2097). For unstrained large unilamellar vesicles, the elastic free energy for membrane insertion is predicted to depend on the fourth power of the membrane thickness. The influence of thermally induced bending fluctuations on the effective tilt of the OmpA β-barrel in disaturated phosphatidylcholine membranes of different thicknesses (Ramakrishnan, M., J.Qu, C. L. Pocanschi, J. H. Kleinschmidt, and D. Marsh. 2005. Biochemistry. 44:3515 3523) is also considered. A contribution to the orientational order parameter that scales as the inverse second power of the membrane thickness is predicted.</dcterms:abstract> <dcterms:isPartOf rdf:resource=""/> <dc:date rdf:datatype="">2011-03-24T17:32:09Z</dc:date> <dcterms:issued>2006</dcterms:issued> <dspace:hasBitstream rdf:resource=""/> <bibo:uri rdf:resource=""/> <dc:creator>Kleinschmidt, Jörg H.</dc:creator> <dc:format>application/pdf</dc:format> <dspace:isPartOfCollection rdf:resource=""/> <dc:creator>Marsh, Derek</dc:creator> <dcterms:bibliographicCitation>First publ. in: Biophysical Journal 91 (2006), 1, pp. 227-232</dcterms:bibliographicCitation> <dc:contributor>Marsh, Derek</dc:contributor> <dc:contributor>Kleinschmidt, Jörg H.</dc:contributor> <dcterms:hasPart rdf:resource=""/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:rights rdf:resource=""/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Shanmugavadivu, Baladhandapani</dc:creator> <dcterms:title>Membrane elastic fluctuations and the insertion and tilt of beta-barrel proteins</dcterms:title> </rdf:Description> </rdf:RDF>

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