The Nucleolus and PARP1 in Cancer Biology

Cite This

Files in this item

Checksum: MD5:d08a8aecc551d607b8c44467d8eee685

ENGBRECHT, Marina, Aswin MANGERICH, 2020. The Nucleolus and PARP1 in Cancer Biology. In: Cancers. MDPI. 12(7), pp. 1813. eISSN 2072-6694. Available under: doi: 10.3390/cancers12071813

@article{Engbrecht2020-07-06Nucle-50202, title={The Nucleolus and PARP1 in Cancer Biology}, year={2020}, doi={10.3390/cancers12071813}, number={7}, volume={12}, journal={Cancers}, author={Engbrecht, Marina and Mangerich, Aswin} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/50202"> <dc:creator>Mangerich, Aswin</dc:creator> <dcterms:abstract xml:lang="eng">The nucleolus has been known for a long time to fulfill crucial functions in ribosome biogenesis, of which cancer cells can become addicted to in order to produce sufficient amounts of proteins for cell proliferation. Recently, the nucleolus has emerged as a central regulatory hub in many other cancer-relevant processes, including stress sensing, DNA damage response, cell cycle control, and proteostasis. This fostered the idea that nucleolar processes can be exploited in cancer therapy. Interestingly, a significant proportion of poly(ADP-ribose) polymerase 1 (PARP1) molecules are localized in the nucleolus and PARP1 also plays crucial roles in many processes that are important in cancer biology, including genome maintenance, replication, transcription, and chromatin remodeling. Furthermore, during the last years, PARP1 came into focus in oncology since it represents a promising target of pharmacological PARP inhibitors in various types of cancers. Here, we provide an overview of our current understanding on the role of PARP1 in nucleolar functions and discuss potential implications in cancer biology and therapy.</dcterms:abstract> <dc:contributor>Mangerich, Aswin</dc:contributor> <dcterms:title>The Nucleolus and PARP1 in Cancer Biology</dcterms:title> <dc:contributor>Engbrecht, Marina</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/50202/1/Engbrecht_2-1y0r8ca2vlgxv3.pdf"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-07-10T07:57:34Z</dc:date> <dc:creator>Engbrecht, Marina</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/50202/1/Engbrecht_2-1y0r8ca2vlgxv3.pdf"/> <dc:language>eng</dc:language> <dcterms:issued>2020-07-06</dcterms:issued> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-07-10T07:57:34Z</dcterms:available> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/50202"/> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by/4.0/"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> </rdf:Description> </rdf:RDF>

Downloads since Jul 10, 2020 (Information about access statistics)

Engbrecht_2-1y0r8ca2vlgxv3.pdf 73

This item appears in the following Collection(s)

https://creativecommons.org/licenses/by/4.0/ Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0/

Search KOPS


Browse

My Account