KOPS - The Institutional Repository of the University of Konstanz

Hyperfunctioning of the right posterior superior temporal sulcus in response to neutral facial expressions presents an endophenotype of schizophrenia

Hyperfunctioning of the right posterior superior temporal sulcus in response to neutral facial expressions presents an endophenotype of schizophrenia

Cite This

Files in this item

Files Size Format View

There are no files associated with this item.

YAN, Zhimin, Stephanie N. L. SCHMIDT, Josef FRANK, Stephanie H. WITT, Joachim HASS, Peter KIRSCH, Daniela MIER, 2020. Hyperfunctioning of the right posterior superior temporal sulcus in response to neutral facial expressions presents an endophenotype of schizophrenia. In: Neuropsychopharmacology. Springer Nature. ISSN 0893-133X. eISSN 1740-634X. Available under: doi: 10.1038/s41386-020-0637-8

@article{Yan2020-02-14Hyper-49041, title={Hyperfunctioning of the right posterior superior temporal sulcus in response to neutral facial expressions presents an endophenotype of schizophrenia}, year={2020}, doi={10.1038/s41386-020-0637-8}, issn={0893-133X}, journal={Neuropsychopharmacology}, author={Yan, Zhimin and Schmidt, Stephanie N. L. and Frank, Josef and Witt, Stephanie H. and Hass, Joachim and Kirsch, Peter and Mier, Daniela} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/49041"> <dc:creator>Frank, Josef</dc:creator> <dc:creator>Hass, Joachim</dc:creator> <dc:contributor>Yan, Zhimin</dc:contributor> <dcterms:issued>2020-02-14</dcterms:issued> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dc:creator>Yan, Zhimin</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Schmidt, Stephanie N. L.</dc:creator> <dc:contributor>Kirsch, Peter</dc:contributor> <dc:creator>Kirsch, Peter</dc:creator> <dc:creator>Mier, Daniela</dc:creator> <dc:contributor>Hass, Joachim</dc:contributor> <dc:creator>Witt, Stephanie H.</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:abstract xml:lang="eng">Deficits in social cognition have been proposed as a marker of schizophrenia. Growing evidence suggests especially hyperfunctioning of the right posterior superior temporal sulcus (pSTS) in response to neutral social stimuli reflecting the neural correlates of social-cognitive impairments in schizophrenia. We characterized healthy participants according to schizotypy (n = 74) and the single-nucleotide polymorphism rs1344706 in ZNF804A (n = 73), as they represent risk variants for schizophrenia from the perspectives of personality traits and genetics, respectively. A social-cognitive fMRI task was applied to investigate the association of right pSTS hyperfunctioning in response to neutral face stimuli with schizotypy and rs1344706. Higher right pSTS activation in response to neutral facial expressions was found in individuals with increased positive (trend) and disorganization symptoms, as well as in carriers of the risk allele of rs1344706. In addition, a positive association between right–left pSTS connectivity and disorganization symptoms during neutral face processing was revealed. Although these findings warrant replication, we suggest that right pSTS hyperfunctioning in response to neutral facial expressions presents an endophenotype of schizophrenia. We assume that right pSTS hyperfunctioning is a vulnerability to perceive neutral social stimuli as emotionally or intentionally salient, probably contributing to the emergence of symptoms of schizophrenia.</dcterms:abstract> <dcterms:title>Hyperfunctioning of the right posterior superior temporal sulcus in response to neutral facial expressions presents an endophenotype of schizophrenia</dcterms:title> <dc:contributor>Mier, Daniela</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>Frank, Josef</dc:contributor> <dc:contributor>Witt, Stephanie H.</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/49041"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-03-13T13:09:06Z</dc:date> <dc:contributor>Schmidt, Stephanie N. L.</dc:contributor> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by/4.0"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2020-03-13T13:09:06Z</dcterms:available> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> </rdf:Description> </rdf:RDF>

This item appears in the following Collection(s)

https://creativecommons.org/licenses/by/4.0 Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0

Search KOPS


Browse

My Account