Advancing human health risk assessment

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LANZONI, Anna, Anna F. CASTOLDI, George E.N. KASS, Andrea TERRON, Guilhem DE SEZE, Anna BAL‐PRICE, Frédéric Y. BOIS, K. Barry DELCLOS, Daniel R. DOERGE, Marcel LEIST, 2019. Advancing human health risk assessment. In: EFSA Journal. 17(S1), e170712. eISSN 1831-4732. Available under: doi: 10.2903/j.efsa.2019.e170712

@article{Lanzoni2019-07Advan-46397, title={Advancing human health risk assessment}, year={2019}, doi={10.2903/j.efsa.2019.e170712}, number={S1}, volume={17}, journal={EFSA Journal}, author={Lanzoni, Anna and Castoldi, Anna F. and Kass, George E.N. and Terron, Andrea and De Seze, Guilhem and Bal‐Price, Anna and Bois, Frédéric Y. and Delclos, K. Barry and Doerge, Daniel R. and Leist, Marcel}, note={Article Number: e170712} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/46397"> <dc:contributor>Delclos, K. Barry</dc:contributor> <dc:creator>Castoldi, Anna F.</dc:creator> <dc:creator>Lanzoni, Anna</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/46397/3/Lanzoni_2-1vwwv1tu4kdc07.pdf"/> <dc:contributor>Terron, Andrea</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:issued>2019-07</dcterms:issued> <dcterms:title>Advancing human health risk assessment</dcterms:title> <dc:creator>Leist, Marcel</dc:creator> <dc:creator>Bois, Frédéric Y.</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/46397"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Terron, Andrea</dc:creator> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dc:rights>terms-of-use</dc:rights> <dc:creator>Bal‐Price, Anna</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-07-16T12:35:58Z</dcterms:available> <dc:contributor>Lanzoni, Anna</dc:contributor> <dc:contributor>Bal‐Price, Anna</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>De Seze, Guilhem</dc:contributor> <dc:creator>Kass, George E.N.</dc:creator> <dc:contributor>Leist, Marcel</dc:contributor> <dc:contributor>Castoldi, Anna F.</dc:contributor> <dc:creator>De Seze, Guilhem</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-07-16T12:35:58Z</dc:date> <dc:contributor>Bois, Frédéric Y.</dc:contributor> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/46397/3/Lanzoni_2-1vwwv1tu4kdc07.pdf"/> <dc:creator>Doerge, Daniel R.</dc:creator> <dcterms:abstract xml:lang="eng">The current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current approach is considered too resource intensive, is not always reliable, can raise issues of reproducibility, is mostly animal based and does not necessarily provide an understanding of the underlying mechanisms of toxicity. From an ethical and scientific viewpoint, a paradigm shift is required to deliver testing strategies that enable reliable, animal‐free hazard and risk assessments, which are based on a mechanistic understanding of chemical toxicity and make use of exposure science and epidemiological data. This shift will require a new philosophy, new data, multidisciplinary expertise and more flexible regulations. Re‐engineering of available data is also deemed necessary as data should be accessible, readable, interpretable and usable. Dedicated training to build the capacity in terms of expertise is necessary, together with practical resources allocated to education. The dialogue between risk assessors, risk managers, academia and stakeholders should be promoted further to understand scientific and societal needs. Genuine interest in taking risk assessment forward should drive the change and should be supported by flexible funding. This publication builds upon presentations made and discussions held during the break‐out session ‘Advancing risk assessment science – Human health’ at EFSA's third Scientific Conference ‘Science, Food and Society’ (Parma, Italy, 18–21 September 2018).</dcterms:abstract> <dc:creator>Delclos, K. Barry</dc:creator> <dc:contributor>Kass, George E.N.</dc:contributor> <dc:contributor>Doerge, Daniel R.</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> </rdf:Description> </rdf:RDF>

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