KOPS - The Institutional Repository of the University of Konstanz

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

Cite This

Files in this item

Checksum: MD5:5d282c860c99e7c06c00a8220dc20d5c

KARLSSON LINNÉR, Richard, Pietro BIROLI, Edward KONG, S. Fleur W. MEDDENS, Robbee WEDOW, Mark Alan FONTANA, Maël LEBRETON, Stephen P. TINO, Urs FISCHBACHER, Jonathan P. BEAUCHAMP, 2019. Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. In: Nature Genetics. 51(2), pp. 245-257. ISSN 1061-4036. eISSN 1546-1718. Available under: doi: 10.1038/s41588-018-0309-3

@article{KarlssonLinner2019-02Genom-46335, title={Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences}, year={2019}, doi={10.1038/s41588-018-0309-3}, number={2}, volume={51}, issn={1061-4036}, journal={Nature Genetics}, pages={245--257}, author={Karlsson Linnér, Richard and Biroli, Pietro and Kong, Edward and Meddens, S. Fleur W. and Wedow, Robbee and Fontana, Mark Alan and Lebreton, Maël and Tino, Stephen P. and Fischbacher, Urs and Beauchamp, Jonathan P.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/46335"> <dc:creator>Biroli, Pietro</dc:creator> <dcterms:issued>2019-02</dcterms:issued> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-07-11T13:41:16Z</dcterms:available> <dc:contributor>Meddens, S. Fleur W.</dc:contributor> <dcterms:abstract xml:lang="eng">Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated ([Formula: see text]  ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.</dcterms:abstract> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/46335/1/Karlsson-Linn%c3%a9r_2-1gx2pkejoxvtl5.pdf"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/46"/> <dc:contributor>Fontana, Mark Alan</dc:contributor> <dc:creator>Kong, Edward</dc:creator> <dc:creator>Tino, Stephen P.</dc:creator> <dc:contributor>Lebreton, Maël</dc:contributor> <dc:creator>Karlsson Linnér, Richard</dc:creator> <dc:contributor>Wedow, Robbee</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/46335/1/Karlsson-Linn%c3%a9r_2-1gx2pkejoxvtl5.pdf"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-07-11T13:41:16Z</dc:date> <dcterms:title>Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences</dcterms:title> <dc:contributor>Biroli, Pietro</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/46335"/> <dc:creator>Lebreton, Maël</dc:creator> <dc:contributor>Karlsson Linnér, Richard</dc:contributor> <dc:creator>Wedow, Robbee</dc:creator> <dc:contributor>Beauchamp, Jonathan P.</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Meddens, S. Fleur W.</dc:creator> <dc:contributor>Tino, Stephen P.</dc:contributor> <dc:creator>Beauchamp, Jonathan P.</dc:creator> <dc:creator>Fischbacher, Urs</dc:creator> <dc:contributor>Fischbacher, Urs</dc:contributor> <dcterms:rights rdf:resource="https://kops.uni-konstanz.de/page/termsofuse"/> <dc:language>eng</dc:language> <dc:contributor>Kong, Edward</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:rights>terms-of-use</dc:rights> <dc:creator>Fontana, Mark Alan</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/46"/> </rdf:Description> </rdf:RDF>

Downloads since Jul 11, 2019 (Information about access statistics)

Karlsson-Linnér_2-1gx2pkejoxvtl5.pdf 12

This item appears in the following Collection(s)

Search KOPS


Browse

My Account