KOPS - The Institutional Repository of the University of Konstanz

Genome of the Malawi golden cichlid fish (Melanochromis auratus) reveals exon loss of oca2 in an amelanistic morph

Genome of the Malawi golden cichlid fish (Melanochromis auratus) reveals exon loss of oca2 in an amelanistic morph

Cite This

Files in this item

Checksum: MD5:9d3e7e818799aef8e4039d9ce62ed813

KRATOCHWIL, Claudius F., Sabine URBAN, Axel MEYER, 2019. Genome of the Malawi golden cichlid fish (Melanochromis auratus) reveals exon loss of oca2 in an amelanistic morph. In: Pigment Cell & Melanoma Research. 32(5). ISSN 1755-1471. eISSN 1755-148X. Available under: doi: 10.1111/pcmr.12799

@article{Kratochwil2019-09Genom-46058, title={Genome of the Malawi golden cichlid fish (Melanochromis auratus) reveals exon loss of oca2 in an amelanistic morph}, year={2019}, doi={10.1111/pcmr.12799}, number={5}, volume={32}, issn={1755-1471}, journal={Pigment Cell & Melanoma Research}, author={Kratochwil, Claudius F. and Urban, Sabine and Meyer, Axel} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/46058"> <dc:rights>terms-of-use</dc:rights> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:title>Genome of the Malawi golden cichlid fish (Melanochromis auratus) reveals exon loss of oca2 in an amelanistic morph</dcterms:title> <dc:creator>Urban, Sabine</dc:creator> <dc:contributor>Urban, Sabine</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/46058"/> <dc:contributor>Kratochwil, Claudius F.</dc:contributor> <dc:creator>Meyer, Axel</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-06-19T12:41:35Z</dcterms:available> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Meyer, Axel</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Kratochwil, Claudius F.</dc:creator> <dc:language>eng</dc:language> <dcterms:issued>2019-09</dcterms:issued> <dcterms:abstract xml:lang="eng">The tropical freshwater fish family Cichlidae is famous for its record-breaking rates of speciation and diversity in colors and color patterns. Here, we sequenced the genome of the Lake Malawi cichlid Melanochromis auratus to study the genetic basis of an amelanistic morph of this species that lacks the typical melanic stripes and markings. Genome sequencing of the amelanistic and wild-type morph revealed the loss of the second exon of the known pigmentation gene oculocutaneous albinism II (oca2), also known as p(ink-eyed dilution) gene or melanocyte-specific transporter gene. Additional genotyping confirms the complete association with this recessive Mendelian phenotype. The deletion results in a shorter transcript, lacking an acidic di-leucine domain that is crucial for trafficking of the Oca2 protein to melanosomes. The fact that oca2 is involved in a wide range of amelanistic morphs across vertebrates demonstrates its highly conserved function.</dcterms:abstract> <dcterms:rights rdf:resource="https://kops.uni-konstanz.de/page/termsofuse"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2019-06-19T12:41:35Z</dc:date> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> </rdf:Description> </rdf:RDF>

Downloads since Jun 19, 2019 (Information about access statistics)

Kratochwil_2-eovu0viy3dcp7.pdf 1

This item appears in the following Collection(s)

Search KOPS


Browse

My Account