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Mechanism of the Antiproliferative Activity of Some Naphthalene Diimide G-Quadruplex Ligands

Mechanism of the Antiproliferative Activity of Some Naphthalene Diimide G-Quadruplex Ligands

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HAMPEL, Sonja M., Antonella PEPE, Karin M. GREULICH-BODE, Sanjay V. MALHOTRA, Anthony P. RESZKA, Sebastian VEITH, Petra BOUKAMP, Stephen NEIDLE, 2013. Mechanism of the Antiproliferative Activity of Some Naphthalene Diimide G-Quadruplex Ligands. In: Molecular Pharmacology. 83(2), pp. 470-480. ISSN 0026-895X. eISSN 1521-0111. Available under: doi: 10.1124/mol.112.081075

@article{Hampel2013-02Mecha-42472, title={Mechanism of the Antiproliferative Activity of Some Naphthalene Diimide G-Quadruplex Ligands}, year={2013}, doi={10.1124/mol.112.081075}, number={2}, volume={83}, issn={0026-895X}, journal={Molecular Pharmacology}, pages={470--480}, author={Hampel, Sonja M. and Pepe, Antonella and Greulich-Bode, Karin M. and Malhotra, Sanjay V. and Reszka, Anthony P. and Veith, Sebastian and Boukamp, Petra and Neidle, Stephen} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/42472"> <dc:creator>Hampel, Sonja M.</dc:creator> <dc:contributor>Reszka, Anthony P.</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/42472"/> <dc:contributor>Boukamp, Petra</dc:contributor> <dc:contributor>Malhotra, Sanjay V.</dc:contributor> <dc:creator>Neidle, Stephen</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-05-30T09:37:26Z</dc:date> <dc:contributor>Veith, Sebastian</dc:contributor> <dc:contributor>Neidle, Stephen</dc:contributor> <dc:creator>Boukamp, Petra</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2018-05-30T09:37:26Z</dcterms:available> <dc:creator>Greulich-Bode, Karin M.</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Pepe, Antonella</dc:creator> <dc:creator>Veith, Sebastian</dc:creator> <dcterms:title>Mechanism of the Antiproliferative Activity of Some Naphthalene Diimide G-Quadruplex Ligands</dcterms:title> <dc:creator>Malhotra, Sanjay V.</dc:creator> <dc:contributor>Pepe, Antonella</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>Hampel, Sonja M.</dc:contributor> <dcterms:abstract xml:lang="eng">G-quadruplexes are higher-order nucleic acid structures that can form in G-rich telomeres and promoter regions of oncogenes. Telomeric quadruplex stabilization by small molecules can lead to telomere uncapping, followed by DNA damage response and senescence, as well as chromosomal fusions leading to deregulation of mitosis, followed by apoptosis and downregulation of oncogene expression. We report here on investigations into the mechanism of action of tetra-substituted naphthalene diimide ligands on the basis of cell biologic data together with a National Cancer Institute COMPARE study. We conclude that four principal mechanisms of action are implicated for these compounds: 1) telomere uncapping with subsequent DNA damage response and senescence; 2) inhibition of transcription/translation of oncogenes; 3) genomic instability through telomeric DNA end fusions, resulting in mitotic catastrophe and apoptosis; and 4) induction of chromosomal instability by telomere aggregate formation.</dcterms:abstract> <dc:contributor>Greulich-Bode, Karin M.</dc:contributor> <dc:creator>Reszka, Anthony P.</dc:creator> <dcterms:issued>2013-02</dcterms:issued> </rdf:Description> </rdf:RDF>

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