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Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance

Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance

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Prüfsumme: MD5:e993ccc45cb9f90de54d535d58bb5708

LEE, Jieun, Joseph CHOI, Ebru S. SELEN ALPERGIN, Liang ZHAO, Thomas HARTUNG, Susanna SCAFIDI, Ryan C. RIDDLE, Michael J. WOLFGANG, 2017. Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance. In: Cell Reports. 20(3), pp. 655-667. eISSN 2211-1247. Available under: doi: 10.1016/j.celrep.2017.06.080

@article{Lee2017-07Hepat-40340, title={Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance}, year={2017}, doi={10.1016/j.celrep.2017.06.080}, number={3}, volume={20}, journal={Cell Reports}, pages={655--667}, author={Lee, Jieun and Choi, Joseph and Selen Alpergin, Ebru S. and Zhao, Liang and Hartung, Thomas and Scafidi, Susanna and Riddle, Ryan C. and Wolfgang, Michael J.} }

Choi, Joseph Riddle, Ryan C. 2017-07 Riddle, Ryan C. Wolfgang, Michael J. Selen Alpergin, Ebru S. 2017-10-13T13:13:42Z Lee, Jieun Scafidi, Susanna Hartung, Thomas Wolfgang, Michael J. The liver has a large capacity for mitochondrial fatty acid β-oxidation, which is critical for systemic metabolic adaptations such as gluconeogenesis and ketogenesis. To understand the role of hepatic fatty acid oxidation in response to a chronic high-fat diet (HFD), we generated mice with a liver-specific deficiency of mitochondrial long-chain fatty acid β-oxidation (Cpt2<sup>L-/-</sup> mice). Paradoxically, Cpt2<sup>L-/-</sup> mice were resistant to HFD-induced obesity and glucose intolerance with an absence of liver damage, although they exhibited serum dyslipidemia, hepatic oxidative stress, and systemic carnitine deficiency. Feeding an HFD induced hepatokines in mice, with a loss of hepatic fatty acid oxidation that enhanced systemic energy expenditure and suppressed adiposity. Additionally, the suppression in hepatic gluconeogenesis was sufficient to improve HFD-induced glucose intolerance. These data show that inhibiting hepatic fatty acid oxidation results in a systemic hormetic response that protects mice from HFD-induced obesity and glucose intolerance. Selen Alpergin, Ebru S. 2017-10-13T13:13:42Z Zhao, Liang Hartung, Thomas Loss of Hepatic Mitochondrial Long-Chain Fatty Acid Oxidation Confers Resistance to Diet-Induced Obesity and Glucose Intolerance Choi, Joseph Zhao, Liang eng Lee, Jieun Scafidi, Susanna

Dateiabrufe seit 13.10.2017 (Informationen über die Zugriffsstatistik)

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