Type of Publication: | Journal article |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-0-287334 |
Author: | Owald, David; Felsenberg, Johannes; Talbot, Clifford B.; Das, Gaurav; Perisse, Emmanuel; Huetteroth, Wolf; Waddell, Scott |
Year of publication: | 2015 |
Published in: | Neuron ; 86 (2015), 2. - pp. 417-427. - ISSN 0896-6273. - eISSN 1097-4199 |
Pubmed ID: | 25864636 |
URL of original publication: | http://www.sciencedirect.com/science/article/pii/S0896627315002214, Last access on May 6, 2015 |
DOI (citable link): | https://dx.doi.org/10.1016/j.neuron.2015.03.025 |
Summary: |
During olfactory learning in fruit flies, dopaminergic neurons assign value to odor representations in the mushroom body Kenyon cells. Here we identify a class of downstream glutamatergic mushroom body output neurons (MBONs) called M4/6, or MBON-β2β'2a, MBON-β'2mp, and MBON-γ5β'2a, whose dendritic fields overlap with dopaminergic neuron projections in the tips of the β, β', and γ lobes. This anatomy and their odor tuning suggests that M4/6 neurons pool odor-driven Kenyon cell synaptic outputs. Like that of mushroom body neurons, M4/6 output is required for expression of appetitive and aversive memory performance. Moreover, appetitive and aversive olfactory conditioning bidirectionally alters the relative odor-drive of M4β' neurons (MBON-β'2mp). Direct block of M4/6 neurons in naive flies mimics appetitive conditioning, being sufficient to convert odor-driven avoidance into approach, while optogenetically activating these neurons induces avoidance behavior. We therefore propose that drive to the M4/6 neurons reflects odor-directed behavioral choice.
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Subject (DDC): | 570 Biosciences, Biology |
Keywords: | Drosophila, learning, memory, glutamate, optogenetics, behavior, mushroom body |
Link to License: | In Copyright |
Bibliography of Konstanz: | Yes |
OWALD, David, Johannes FELSENBERG, Clifford B. TALBOT, Gaurav DAS, Emmanuel PERISSE, Wolf HUETTEROTH, Scott WADDELL, 2015. Activity of Defined Mushroom Body Output Neurons Underlies Learned Olfactory Behavior in Drosophila. In: Neuron. 86(2), pp. 417-427. ISSN 0896-6273. eISSN 1097-4199. Available under: doi: 10.1016/j.neuron.2015.03.025
@article{Owald2015Activ-30898, title={Activity of Defined Mushroom Body Output Neurons Underlies Learned Olfactory Behavior in Drosophila}, url={http://www.sciencedirect.com/science/article/pii/S0896627315002214}, year={2015}, doi={10.1016/j.neuron.2015.03.025}, number={2}, volume={86}, issn={0896-6273}, journal={Neuron}, pages={417--427}, author={Owald, David and Felsenberg, Johannes and Talbot, Clifford B. and Das, Gaurav and Perisse, Emmanuel and Huetteroth, Wolf and Waddell, Scott} }
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