Type of Publication: | Journal article |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-0-276866 |
Author: | Wirtz, Petra H.; Ehlert, Ulrike; Emini, Luljeta; Suter, Tobias |
Year of publication: | 2008 |
Published in: | Psychoneuroendocrinology ; 33 (2008), 8. - pp. 1102-1110. - ISSN 0306-4530. - eISSN 1873-3360 |
Pubmed ID: | 18644679 |
DOI (citable link): | https://dx.doi.org/10.1016/j.psyneuen.2008.05.002 |
Summary: |
Background: Body mass index (BMI) and mental stress seem to exert part of their cardiovascular
risk by eliciting inflammation. However, the adverse effects of stress on inflammatory activity
with BMI are not fully understood. We investigated whether higher BMI is associated with reduced
glucocorticoid inhibition of inflammatory cytokine production following stress in men while
controlling for age and blood pressure. We measured glucorticoid inhibition of lipopolysaccharide
(LPS)-stimulated release of the proinflammatory cytokine tumor necrosis factor (TNF)-a.
Methods: Forty-two men (age range 21—65 years; BMI range 21—34 kg/m2) underwent the Trier
Social Stress Test (combination of mock job interview and mental arithmetic task). Whole blood
samples were taken immediately before and after stress, and during recovery up to 60 min poststress.
Glucocorticoid sensitivity of LPS-stimulated TNF-a expression was assessed in vitro with and
without coincubating increasing doses of dexamethasone. Moreover, salivary cortisol wasmeasured
during the experiment and on a normal day for assessment of baseline circadian cortisol.
Results: Higher BMI was associated with lower glucocorticoid sensitivity of monocyte TNF-a
production after stress (main effect of BMI: p < 0.001) and with more pronounced decreases of
glucocorticoid sensitivity following stress (interaction of stress-by-BMI: p = 0.002). Neither LPSstimulated
TNF-a release nor baseline glucocorticoid sensitivity were associated with BMI.
Similarly, BMI was not associated with salivary cortisol, either in reaction to stress or in circadian
cortisol secretion.
Conclusions: Our data suggest that with increasing BMI, glucocorticoids are less able to inhibit
TNF-a production following stress. This might suggest a new mechanism linking BMI with elevated
risk for adverse cardiovascular outcomes following stress.
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Subject (DDC): | 150 Psychology |
Keywords: | BMI; Atherosclerosis; Stress; Glucocorticoid sensitivity; TNF-α |
Link to License: | In Copyright |
WIRTZ, Petra H., Ulrike EHLERT, Luljeta EMINI, Tobias SUTER, 2008. Higher body mass index (BMI) is associated with reduced glucocorticoid inhibition of inflammatory cytokine production following acute psychosocial stress in men. In: Psychoneuroendocrinology. 33(8), pp. 1102-1110. ISSN 0306-4530. eISSN 1873-3360. Available under: doi: 10.1016/j.psyneuen.2008.05.002
@article{Wirtz2008Highe-30752, title={Higher body mass index (BMI) is associated with reduced glucocorticoid inhibition of inflammatory cytokine production following acute psychosocial stress in men}, year={2008}, doi={10.1016/j.psyneuen.2008.05.002}, number={8}, volume={33}, issn={0306-4530}, journal={Psychoneuroendocrinology}, pages={1102--1110}, author={Wirtz, Petra H. and Ehlert, Ulrike and Emini, Luljeta and Suter, Tobias} }
Wirtz_0-276866.pdf | 664 |