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Effect of oral melatonin on the procoagulant response to acute psychosocial stress in healthy men : a randomized placebo-controlled study

Effect of oral melatonin on the procoagulant response to acute psychosocial stress in healthy men : a randomized placebo-controlled study

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WIRTZ, Petra H., Carmen BÄRTSCHI, Maria SPILLMANN, Ulrike EHLERT, Roland VON KÄNEL, 2008. Effect of oral melatonin on the procoagulant response to acute psychosocial stress in healthy men : a randomized placebo-controlled study. In: Journal of Pineal Research. 44(4), pp. 358-365. ISSN 0742-3098. eISSN 1600-079X. Available under: doi: 10.1111/j.1600-079X.2007.00535.x

@article{Wirtz2008Effec-30692, title={Effect of oral melatonin on the procoagulant response to acute psychosocial stress in healthy men : a randomized placebo-controlled study}, year={2008}, doi={10.1111/j.1600-079X.2007.00535.x}, number={4}, volume={44}, issn={0742-3098}, journal={Journal of Pineal Research}, pages={358--365}, author={Wirtz, Petra H. and Bärtschi, Carmen and Spillmann, Maria and Ehlert, Ulrike and von Känel, Roland} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/30692"> <dcterms:abstract xml:lang="eng">Acute mental stress is a potent trigger of acute coronary syndromes. Catecholamine-induced hypercoagulability with acute stress contributes to thrombus growth after coronary plaque rupture. Melatonin may diminish catecholamine activity. We hypothesized that melatonin mitigates the acute procoagulant stress response and that this effect is accompanied by a decrease in the stress-induced catecholamine surge. Forty-five healthy young men received a single oral dose of either 3 mg melatonin (n = 24) or placebo medication (n = 21). One hour thereafter, they underwent a standardized short-term psychosocial stressor. Plasma levels of clotting factor VII activity (FVII:C), FVIII:C, fibrinogen, D-dimer, and catecholamines were measured at rest, immediately after stress, and 20 min and 60 min post-stress. The integrated change in D-dimer levels from rest to 60 min post-stress differed between medication groups controlling for demographic and metabolic factors (P = 0.047, eta(p)(2) = 0.195). Compared with the melatonin group, the placebo group showed a greater increase in absolute D-dimer levels from rest to immediately post-stress (P = 0.13; eta(p)(2) = 0.060) and significant recovery of D-dimer levels from immediately post-stress to 60 min thereafter (P = 0.007; eta(p)(2) = 0.174). Stress-induced changes in FVII:C, FVIII:C, fibrinogen, and catecholamines did not significantly differ between groups. Oral melatonin attenuated the stress-induced elevation in the sensitive coagulation activation marker D-dimer without affecting catecholamine activity. The finding provides preliminary support for a protective effect of melatonin in reducing the atherothrombotic risk with acute mental stress.</dcterms:abstract> <dc:contributor>Wirtz, Petra H.</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dc:creator>Wirtz, Petra H.</dc:creator> <dc:creator>Bärtschi, Carmen</dc:creator> <dc:language>eng</dc:language> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/43"/> <dc:contributor>Spillmann, Maria</dc:contributor> <dc:contributor>Ehlert, Ulrike</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/30692"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/30692/1/Wirtz_0-276890.pdf"/> <dc:creator>von Känel, Roland</dc:creator> <dc:creator>Spillmann, Maria</dc:creator> <dcterms:title>Effect of oral melatonin on the procoagulant response to acute psychosocial stress in healthy men : a randomized placebo-controlled study</dcterms:title> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-04-09T07:00:11Z</dc:date> <dcterms:issued>2008</dcterms:issued> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2015-04-09T07:00:11Z</dcterms:available> <dc:creator>Ehlert, Ulrike</dc:creator> <dc:contributor>Bärtschi, Carmen</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>von Känel, Roland</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.de/urn:nbn:de:bsz:352-20150305140228786-3747162-5"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/30692/1/Wirtz_0-276890.pdf"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 09.04.2015 (Informationen über die Zugriffsstatistik)

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