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Norepinephrine infusion with and without alpha-adrenergic blockade by phentolamine increases salivary alpha amylase in healthy men

Norepinephrine infusion with and without alpha-adrenergic blockade by phentolamine increases salivary alpha amylase in healthy men

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KUEBLER, Ulrike, Roland VON KÄNEL, Nadja HEIMGARTNER, Claudia ZUCCARELLA-HACKL, Guido STIRNIMANN, Ulrike EHLERT, Petra H. WIRTZ, 2014. Norepinephrine infusion with and without alpha-adrenergic blockade by phentolamine increases salivary alpha amylase in healthy men. In: Psychoneuroendocrinology. 49, pp. 290-298. ISSN 0306-4530. eISSN 1873-3360. Available under: doi: 10.1016/j.psyneuen.2014.07.023

@article{Kuebler2014Norep-29654, title={Norepinephrine infusion with and without alpha-adrenergic blockade by phentolamine increases salivary alpha amylase in healthy men}, year={2014}, doi={10.1016/j.psyneuen.2014.07.023}, volume={49}, issn={0306-4530}, journal={Psychoneuroendocrinology}, pages={290--298}, author={Kuebler, Ulrike and von Känel, Roland and Heimgartner, Nadja and Zuccarella-Hackl, Claudia and Stirnimann, Guido and Ehlert, Ulrike and Wirtz, Petra H.} }

von Känel, Roland 2015-01-29T14:41:57Z Norepinephrine infusion with and without alpha-adrenergic blockade by phentolamine increases salivary alpha amylase in healthy men Heimgartner, Nadja Wirtz, Petra H. Background<br />Mental stress reliably induces increases in salivary alpha amylase (sAA), a suggested surrogate marker for sympathetic nervous system (SNS) reactivity. While stress-induced sAA increases correlate with norepinephrine (NE) secretion, a potential mediating role of noradrenergic mechanisms remains unclear. In this study, we investigated for the first time in humans whether a NE-stress-reactivity mimicking NE-infusion with and without alpha-adrenergic blockade by phentolamine would induce changes in sAA.<br /><br />Methods<br />In a single-blind placebo-controlled within-subjects design, 21 healthy men (29–66 years) took part in three different experimental trials varying in terms of substance infusion with a 1-min first infusion followed by a 15-min second infusion: saline-infusion (trial-1), NE-infusion (5 μg/min) without alpha-adrenergic blockade (trial-2), and with phentolamine-induced non-selective blockade of alpha1- and alpha2-adrenergic receptors (trial-3). Saliva samples were collected immediately before, during, and several times after substance infusion in addition to blood pressure and heart rate readings.<br /><br />Results<br />Experimental trials significantly differed in sAA reactivity to substance-infusion (p = .001) with higher sAA reactivity following NE-infusion with (trial-3; p = .001) and without alpha-adrenergic-blockade (trial-2; p = .004) as compared to placebo-infusion (trial-1); sAA infusion reactivity did not differ between trial-2 and trial-3 (p = .29). Effective phentolamine application was verified by blood pressure and heart rate infusion reactivity. Salivary cortisol was not affected by NE, either with or without alpha-adrenergic-blockade.<br /><br />Conclusions<br />We found that NE-infusion stimulates sAA secretion, regardless of co-administered non-selective alpha-adrenergic blockade by phentolamine, suggesting that the mechanism underlying stress-induced sAA increases may involve NE. 2014 Zuccarella-Hackl, Claudia Stirnimann, Guido eng Ehlert, Ulrike Kuebler, Ulrike Stirnimann, Guido Ehlert, Ulrike Heimgartner, Nadja Zuccarella-Hackl, Claudia 2015-01-29T14:41:57Z von Känel, Roland Wirtz, Petra H. Kuebler, Ulrike

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