Regulation of chromatin structure by poly(ADP-ribosyl)ation

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BENEKE, Sascha, 2012. Regulation of chromatin structure by poly(ADP-ribosyl)ation. In: Frontiers in Genetics. 3, 169. eISSN 1664-8021. Available under: doi: 10.3389/fgene.2012.00169

@article{Beneke2012Regul-29471, title={Regulation of chromatin structure by poly(ADP-ribosyl)ation}, year={2012}, doi={10.3389/fgene.2012.00169}, volume={3}, journal={Frontiers in Genetics}, author={Beneke, Sascha}, note={Article Number: 169} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:contributor>Beneke, Sascha</dc:contributor> <dc:rights>Attribution 3.0 Unported</dc:rights> <dcterms:issued>2012</dcterms:issued> <dcterms:available rdf:datatype="">2015-01-07T12:57:44Z</dcterms:available> <dcterms:isPartOf rdf:resource=""/> <dcterms:rights rdf:resource=""/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:title>Regulation of chromatin structure by poly(ADP-ribosyl)ation</dcterms:title> <dspace:hasBitstream rdf:resource=""/> <dc:language>eng</dc:language> <dc:date rdf:datatype="">2015-01-07T12:57:44Z</dc:date> <dcterms:abstract xml:lang="eng">The interaction of DNA with proteins in the context of chromatin has to be tightly regulated to achieve so different tasks as packaging, transcription, replication and repair. The very rapid and transient post-translational modification of proteins by poly(ADP-ribose) has been shown to take part in all four. Originally identified as immediate cellular answer to a variety of genotoxic stresses, already early data indicated the ability of this highly charged nucleic acid-like polymer to modulate nucleosome structure, the basic unit of chromatin. At the same time the enzyme responsible for synthesizing poly(ADP-ribose), the zinc-finger protein poly(ADP-ribose) polymerase-1 (PARP1), was shown to control transcription initiation as basic factor TFIIC within the RNA-polymerase II machinery. Later research focused more on PARP-mediated regulation of DNA repair and cell death, but in the last few years, transcription as well as chromatin modulation has re-appeared on the scene. This review will discuss the impact of PARP1 on transcription and transcription factors, its implication in chromatin remodeling for DNA repair and probably also replication, and its role in controlling epigenetic events such as DNA methylation and the functionality of the insulator protein CCCTC-binding factor.</dcterms:abstract> <dcterms:hasPart rdf:resource=""/> <bibo:uri rdf:resource=""/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Beneke, Sascha</dc:creator> <dspace:isPartOfCollection rdf:resource=""/> </rdf:Description> </rdf:RDF>

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