Intracellular calcium channels in protozoa

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DOCAMPO, Roberto, Silvia N J MORENO, Helmut PLATTNER, 2014. Intracellular calcium channels in protozoa. In: European Journal of Pharmacology. 739, pp. 4-18. ISSN 0014-2999. eISSN 1879-0712. Available under: doi: 10.1016/j.ejphar.2013.11.015

@article{Docampo2014-09-15Intra-26804, title={Intracellular calcium channels in protozoa}, year={2014}, doi={10.1016/j.ejphar.2013.11.015}, volume={739}, issn={0014-2999}, journal={European Journal of Pharmacology}, pages={4--18}, author={Docampo, Roberto and Moreno, Silvia N J and Plattner, Helmut} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:issued>2014-09-15</dcterms:issued> <dspace:isPartOfCollection rdf:resource=""/> <dcterms:hasPart rdf:resource=""/> <dcterms:abstract xml:lang="eng">Ca2+-signaling pathways and intracellular Ca2+ channels are present in protozoa. Ancient origin of inositol 1,4,5-trisphosphate receptors (IP3Rs) and other intracellular channels predates the divergence of animals and fungi as evidenced by their presence in the choanoflagellate Monosiga brevicollis, the closest known relative to metazoans. The first protozoan IP3R cloned, from the ciliate Paramecium, displays strong sequence similarity to the rat type 3 IP3R. This ciliate has a large number of IP3- and ryanodine(Ry)-like receptors in six subfamilies suggesting the evolutionary adaptation to local requirements for an expanding diversification of vesicle trafficking. IP3Rs have also been functionally characterized in trypanosomatids, where they are essential for growth, differentiation, and establishment of infection. The presence of the mitochondrial calcium uniporter (MCU) in a number of protozoa indicates that mitochondrial regulation of Ca2+ signaling is also an early appearance in evolution, and contributed to the discovery of the molecular nature of this channel in mammalian cells. There is only sequence evidence for the occurrence of two-pore channels (TPCs), transient receptor potential Ca2+ channels (TRPCs) and intracellular mechanosensitive Ca2+-channels in Paramecium and in parasitic protozoa.</dcterms:abstract> <dcterms:rights rdf:resource=""/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:date rdf:datatype="">2014-03-12T11:16:59Z</dc:date> <dc:contributor>Docampo, Roberto</dc:contributor> <dc:creator>Moreno, Silvia N J</dc:creator> <dcterms:bibliographicCitation>European Journal of Pharmacology ; 739 (2014). - S. 4-18</dcterms:bibliographicCitation> <dc:contributor>Plattner, Helmut</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:isPartOf rdf:resource=""/> <dc:rights>terms-of-use</dc:rights> <dcterms:available rdf:datatype="">2014-03-12T11:16:59Z</dcterms:available> <dc:creator>Docampo, Roberto</dc:creator> <dc:creator>Plattner, Helmut</dc:creator> <dcterms:title>Intracellular calcium channels in protozoa</dcterms:title> <dc:contributor>Moreno, Silvia N J</dc:contributor> <bibo:uri rdf:resource=""/> <dc:language>eng</dc:language> <dspace:hasBitstream rdf:resource=""/> </rdf:Description> </rdf:RDF>

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