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Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides

Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides

Type of Publication: Journal article
URI (citable link): http://nbn-resolving.de/urn:nbn:de:bsz:352-251260
Author: Obeid, Samra; Bußkamp, Holger; Welte, Wolfram; Diederichs, Kay; Marx, Andreas
Year of publication: 2013
Published in: Journal of the American Chemical Society ; 135 (2013), 42. - pp. 15667-15669. - ISSN 0002-7863. - eISSN 1520-5126
Pubmed ID: 24090271
DOI (citable link): https://dx.doi.org/10.1021/ja405346s
Summary:
Functional nucleotides are important in many cutting-edge biomolecular techniques. Often several modified nucleotides have to be incorporated consecutively. This structural study of KlenTaq DNA polymerase, a truncated form of Thermus aquaticus DNA polymerase, gives first insights how multiple modifications are processed by a DNA polymerase and, therefore, contribute to the understanding of these enzymes in their interplay with artificial substrates.
Subject (DDC): 570 Biosciences, Biology
Link to License: In Copyright
Bibliography of Konstanz: Yes

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OBEID, Samra, Holger BUSSKAMP, Wolfram WELTE, Kay DIEDERICHS, Andreas MARX, 2013. Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides. In: Journal of the American Chemical Society. 135(42), pp. 15667-15669. ISSN 0002-7863. eISSN 1520-5126. Available under: doi: 10.1021/ja405346s

@article{Obeid2013-10-23Snaps-25126, title={Snapshot of a DNA Polymerase while Incorporating Two Consecutive C5-Modified Nucleotides}, year={2013}, doi={10.1021/ja405346s}, number={42}, volume={135}, issn={0002-7863}, journal={Journal of the American Chemical Society}, pages={15667--15669}, author={Obeid, Samra and Bußkamp, Holger and Welte, Wolfram and Diederichs, Kay and Marx, Andreas} }

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