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t<sup>4</sup> report : metabolomics in toxicology and preclinical research

t4 report : metabolomics in toxicology and preclinical research

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RAMIREZ, Tzutzuy, Mardas DANESHIAN, Hennicke KAMP, Frederic Y. BOIS, Malcolm R. CLENCH, Muireann COEN, Beth DONLEY, Steven M. FISCHER, Drew R. EKMAN, Eric FABIAN, Claude GUILLOU, Joachim HEUER, Helena T. HOGBERG, Harald JUNGNICKEL, Hector C. KEUN, Gerhard KRENNRICH, Eckart KRUPP, Andreas LUCH, Fozia NOOR, Erik PETER, Bjoern RIEFKE, Mark SEYMOUR, Nigel SKINNER, Lena SMIRNOVA, Elwin VERHEIJ, Silvia WAGNER, Thomas HARTUNG, Bennard VAN RAVENZWAAY, Marcel LEIST, 2013. t4 report : metabolomics in toxicology and preclinical research. In: ALTEX. 30(2), pp. 209-225. ISSN 1868-596X. Available under: doi: 10.14573/altex.2013.2.209

@article{Ramirez2013repor-24424, title={t4 report : metabolomics in toxicology and preclinical research}, year={2013}, doi={10.14573/altex.2013.2.209}, number={2}, volume={30}, issn={1868-596X}, journal={ALTEX}, pages={209--225}, author={Ramirez, Tzutzuy and Daneshian, Mardas and Kamp, Hennicke and Bois, Frederic Y. and Clench, Malcolm R. and Coen, Muireann and Donley, Beth and Fischer, Steven M. and Ekman, Drew R. and Fabian, Eric and Guillou, Claude and Heuer, Joachim and Hogberg, Helena T. and Jungnickel, Harald and Keun, Hector C. and Krennrich, Gerhard and Krupp, Eckart and Luch, Andreas and Noor, Fozia and Peter, Erik and Riefke, Bjoern and Seymour, Mark and Skinner, Nigel and Smirnova, Lena and Verheij, Elwin and Wagner, Silvia and Hartung, Thomas and van Ravenzwaay, Bennard and Leist, Marcel} }

Coen, Muireann Fischer, Steven M. Verheij, Elwin Krennrich, Gerhard Krupp, Eckart Ramirez, Tzutzuy van Ravenzwaay, Bennard 2013-09-18T12:42:15Z Verheij, Elwin 2013 Heuer, Joachim Peter, Erik Kamp, Hennicke Jungnickel, Harald Kamp, Hennicke Donley, Beth Seymour, Mark Hartung, Thomas Hogberg, Helena T. Keun, Hector C. Keun, Hector C. Clench, Malcolm R. Heuer, Joachim Leist, Marcel Ekman, Drew R. Ramirez, Tzutzuy Leist, Marcel Noor, Fozia Coen, Muireann Metabolomics, the comprehensive analysis of metabolites in a biological system, provides detailed information about the biochemical/physiological status of a biological system, and about the changes caused by chemicals. Metabolomics analysis is used in many fields, ranging from the analysis of the physiological status of genetically modified organisms in safety science to the evaluation of human health conditions. In toxicology, metabolomics is the -omics discipline that is most closely related to classical knowledge of disturbed biochemical pathways. It allows rapid identification of the potential targets of a hazardous compound. It can give information on target organs and often can help to improve our understanding regarding the mode-of-action of a given compound. Such insights aid the discovery of biomarkers that either indicate pathophysiological conditions or help the monitoring of the efficacy of drug therapies. The first toxicological applications of metabolomics were for mechanistic research, but different ways to use the technology in a regulatory context are being explored. Ideally, further progress in that direction will position the metabolomics approach to address the challenges of toxicology of the 21st century. To address these issues, scientists from academia, industry, and regulatory bodies came together in a workshop to discuss the current status of applied metabolomics and its potential in the safety assessment of compounds. We report here on the conclusions of three working groups addressing questions regarding 1) metabolomics for in vitro studies 2) the appropriate use of metabolomics in systems toxicology, and 3) use of metabolomics in a regulatory context. Hartung, Thomas van Ravenzwaay, Bennard Smirnova, Lena Guillou, Claude ALTEX ; 30 (2013), 2. - S. 209-225 terms-of-use t<sup>4</sup> report : metabolomics in toxicology and preclinical research Donley, Beth Wagner, Silvia Skinner, Nigel Ekman, Drew R. Luch, Andreas Daneshian, Mardas Wagner, Silvia Clench, Malcolm R. Daneshian, Mardas Smirnova, Lena eng Jungnickel, Harald Luch, Andreas Bois, Frederic Y. Fabian, Eric Riefke, Bjoern Bois, Frederic Y. Noor, Fozia Skinner, Nigel Seymour, Mark Guillou, Claude 2014-08-30T22:25:05Z Peter, Erik Krupp, Eckart Hogberg, Helena T. Krennrich, Gerhard Fabian, Eric Riefke, Bjoern Fischer, Steven M.

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