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A relationship between mechanically-induced changes in serum cartilage oligomeric matrix protein (COMP) and changes in cartilage thickness after 5 years

A relationship between mechanically-induced changes in serum cartilage oligomeric matrix protein (COMP) and changes in cartilage thickness after 5 years

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ERHART-HLEDIK, Jennifer C., Julien FAVRE, Jessica L. ASAY, R. Lane SMITH, Nicolas N. GIORI, Annegret MÜNDERMANN, Thomas P. ANDRIACCHI, 2012. A relationship between mechanically-induced changes in serum cartilage oligomeric matrix protein (COMP) and changes in cartilage thickness after 5 years. In: Osteoarthritis and Cartilage. 20(11), pp. 1309-1315. ISSN 1063-4584. eISSN 1522-9653. Available under: doi: 10.1016/j.joca.2012.07.018

@article{ErhartHledik2012-11relat-22021, title={A relationship between mechanically-induced changes in serum cartilage oligomeric matrix protein (COMP) and changes in cartilage thickness after 5 years}, year={2012}, doi={10.1016/j.joca.2012.07.018}, number={11}, volume={20}, issn={1063-4584}, journal={Osteoarthritis and Cartilage}, pages={1309--1315}, author={Erhart-Hledik, Jennifer C. and Favre, Julien and Asay, Jessica L. and Smith, R. Lane and Giori, Nicolas N. and Mündermann, Annegret and Andriacchi, Thomas P.} }

Favre, Julien Erhart-Hledik, Jennifer C. 2013-02-21T15:15:50Z Smith, R. Lane Andriacchi, Thomas P. Mündermann, Annegret Andriacchi, Thomas P. Giori, Nicolas N. A relationship between mechanically-induced changes in serum cartilage oligomeric matrix protein (COMP) and changes in cartilage thickness after 5 years Erhart-Hledik, Jennifer C. Osteoarthritis and Cartilage ; 20 (2012), 11. - S. 1309-1315 2013-02-21T15:15:50Z Asay, Jessica L. terms-of-use Favre, Julien Giori, Nicolas N. eng Asay, Jessica L. 2012-11 Objective: To evaluate the hypothesis that a mechanical stimulus (30-min walk) will produce a change in serum concentrations of cartilage oligomeric matrix protein (COMP) that is associated with cartilage thickness changes on magnetic resonance imaging (MRI). Methods: Serum COMP concentrations were measured by enzyme-linked immunosorbent assay in 17 patients (11 females, age: 59.0 ` 9.2 years) with medial compartment knee osteoarthritis (OA) at study entry immediately before, immediately after, 3.5 h, and 5.5 h after a 30-min walking activity. Cartilage thickness changes in the medial femur and medial tibia were determined from MR images taken at study entry and at 5-year follow-up. Relationships between changes in cartilage thickness and COMP levels, with post-activity concentrations expressed as a percentage of pre-activity levels, were assessed by the calculation of Pearson correlation coefficients and by multiple linear regression analysis, with adjust- ments for age, sex, and body mass index (BMI).<br />Results: Changes in COMP levels 3.5 h and 5.5 h post-activity were correlated with changes in cartilage thickness in the medial femur and tibia at the 5-year follow-up. The results were strengthened after analyses were adjusted for age, sex, and BMI. Neither baseline pre-activity COMP levels nor changes in COMP levels immediately post-activity were correlated with cartilage thickness changes.<br />Conclusions: The results of this study support the hypothesis that a change in COMP concentration induced by a mechanical stimulus is associated with cartilage thinning at 5 years. Mechanically-induced changes in mechano-sensitive biomarkers should be further explored in the context of stimuluseresponse models to improve the ability to assess OA progression. Smith, R. Lane Mündermann, Annegret

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