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The serotonergic central nervous system of the Drosophila larva : anatomy and behavioral function

The serotonergic central nervous system of the Drosophila larva : anatomy and behavioral function

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HUSER, Annina, Astrid ROHWEDDER, Anthi APOSTOLOPOULOU, Annekathrin WIDMANN, Johanna PFITZENMAIER, Elena M. MAIOLO, Mareike SELCHO, Dennis PAULS, Alina von ESSEN, Tripti GUPTA, Simon G. SPRECHER, Serge BIRMAN, Thomas RIEMENSPERGER, Reinhard F. STOCKER, Andreas THUM, 2012. The serotonergic central nervous system of the Drosophila larva : anatomy and behavioral function. In: PLoS ONE. 7(10), e47518. eISSN 1932-6203. Available under: doi: 10.1371/journal.pone.0047518

@article{Huser2012serot-21762, title={The serotonergic central nervous system of the Drosophila larva : anatomy and behavioral function}, year={2012}, doi={10.1371/journal.pone.0047518}, number={10}, volume={7}, journal={PLoS ONE}, author={Huser, Annina and Rohwedder, Astrid and Apostolopoulou, Anthi and Widmann, Annekathrin and Pfitzenmaier, Johanna and Maiolo, Elena M. and Selcho, Mareike and Pauls, Dennis and Essen, Alina von and Gupta, Tripti and Sprecher, Simon G. and Birman, Serge and Riemensperger, Thomas and Stocker, Reinhard F. and Thum, Andreas}, note={Article Number: e47518} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/21762"> <dc:creator>Widmann, Annekathrin</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/21762/1/Huser_217620.pdf"/> <dc:creator>Pfitzenmaier, Johanna</dc:creator> <dc:contributor>Huser, Annina</dc:contributor> <dc:creator>Huser, Annina</dc:creator> <dc:creator>Pauls, Dennis</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/52"/> <dc:contributor>Thum, Andreas</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:rights rdf:resource="https://rightsstatements.org/page/InC/1.0/"/> <dc:contributor>Stocker, Reinhard F.</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-02-13T13:54:51Z</dcterms:available> <dc:contributor>Birman, Serge</dc:contributor> <dc:contributor>Selcho, Mareike</dc:contributor> <dc:creator>Thum, Andreas</dc:creator> <dcterms:bibliographicCitation>PLoS one ; 7 (2012), 10. - e47518</dcterms:bibliographicCitation> <dc:creator>Selcho, Mareike</dc:creator> <dc:creator>Birman, Serge</dc:creator> <dc:creator>Essen, Alina von</dc:creator> <dc:contributor>Maiolo, Elena M.</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/21762/1/Huser_217620.pdf"/> <dc:contributor>Riemensperger, Thomas</dc:contributor> <dcterms:issued>2012</dcterms:issued> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Rohwedder, Astrid</dc:contributor> <dcterms:abstract xml:lang="eng">The Drosophila larva has turned into a particularly simple model system for studying the neuronal basis of innate behaviors and higher brain functions. Neuronal networks involved in olfaction, gustation, vision and learning and memory have been described during the last decade, often up to the single-cell level. Thus, most of these sensory networks are substantially defined, from the sensory level up to third-order neurons. This is especially true for the olfactory system of the larva. Given the wealth of genetic tools in Drosophila it is now possible to address the question how modulatory systems interfere with sensory systems and affect learning and memory. Here we focus on the serotonergic system that was shown to be involved in mammalian and insect sensory perception as well as learning and memory. Larval studies suggested that the serotonergic system is involved in the modulation of olfaction, feeding, vision and heart rate regulation. In a dual anatomical and behavioral approach we describe the basic anatomy of the larval serotonergic system, down to the singlecell level. In parallel, by expressing apoptosis-inducing genes during embryonic and larval development, we ablate most of the serotonergic neurons within the larval central nervous system. When testing these animals for naı¨ve odor, sugar, salt and light perception, no profound phenotype was detectable; even appetitive and aversive learning was normal. Our results provide the first comprehensive description of the neuronal network of the larval serotonergic system. Moreover, they suggest that serotonin per se is not necessary for any of the behaviors tested. However, our data do not exclude that this system may modulate or fine-tune a wide set of behaviors, similar to its reported function in other insect species or in mammals. Based on our observations and the availability of a wide variety of genetic tools, this issue can now be addressed.</dcterms:abstract> <dcterms:title>The serotonergic central nervous system of the Drosophila larva : anatomy and behavioral function</dcterms:title> <dc:creator>Stocker, Reinhard F.</dc:creator> <dc:rights>terms-of-use</dc:rights> <dc:creator>Rohwedder, Astrid</dc:creator> <dc:creator>Gupta, Tripti</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Apostolopoulou, Anthi</dc:creator> <dc:creator>Maiolo, Elena M.</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/52"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/21762"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2013-02-13T13:54:51Z</dc:date> <dc:contributor>Essen, Alina von</dc:contributor> <dc:contributor>Gupta, Tripti</dc:contributor> <dc:contributor>Sprecher, Simon G.</dc:contributor> <dc:contributor>Pfitzenmaier, Johanna</dc:contributor> <dc:contributor>Widmann, Annekathrin</dc:contributor> <dc:contributor>Apostolopoulou, Anthi</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Sprecher, Simon G.</dc:creator> <dc:language>eng</dc:language> <dc:creator>Riemensperger, Thomas</dc:creator> <dc:contributor>Pauls, Dennis</dc:contributor> </rdf:Description> </rdf:RDF>

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