Nucleocytoplasmic transport in apoptosis

Cite This

Files in this item

Checksum: MD5:0955fc76680ae139a286230d46f69deb

MAY, Elisa, 2005. Nucleocytoplasmic transport in apoptosis. In: Cell Death and Differentiation. 12(10), pp. 1263-1276. ISSN 1350-9047. Available under: doi: 10.1038/sj.cdd.4401626

@article{May2005-10Nucle-18246, title={Nucleocytoplasmic transport in apoptosis}, year={2005}, doi={10.1038/sj.cdd.4401626}, number={10}, volume={12}, issn={1350-9047}, journal={Cell Death and Differentiation}, pages={1263--1276}, author={May, Elisa} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:abstract xml:lang="eng">The apoptotic demolition of the nucleus is accomplished by diverse proapoptotic factors, most of which are activated in the cytoplasm and gain access to the nucleoplasm during the cell death process. The nucleus is also the main target for genotoxic insult, a potent apoptotic trigger. Signals generated in the nucleus by DNA damage have to propagate to all cellular compartments to ensure the coordinated execution of cell demise. The nucleocytoplasmic shuttling of signalling and execution factors is thus an integral part of the apoptotic programme. Several proteins implicated in apoptotic cell death have been shown to migrate in and out of the nucleus following apoptosis induction. This review summarises the current knowledge on nucleocytoplasmic trafficking of apoptosis-relevant proteins. The effects of apoptosis induction on the nucleocytoplasmic transport machinery are also discussed. Finally, a potential role of nuclear transport as a critical control point of the apoptotic signal cascade is proposed.</dcterms:abstract> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dspace:isPartOfCollection rdf:resource=""/> <dcterms:available rdf:datatype="">2012-03-19T12:48:06Z</dcterms:available> <dcterms:rights rdf:resource=""/> <bibo:uri rdf:resource=""/> <dspace:isPartOfCollection rdf:resource=""/> <dcterms:isPartOf rdf:resource=""/> <dcterms:isPartOf rdf:resource=""/> <dc:creator>May, Elisa</dc:creator> <dcterms:title>Nucleocytoplasmic transport in apoptosis</dcterms:title> <dc:contributor>May, Elisa</dc:contributor> <dc:rights>terms-of-use</dc:rights> <dcterms:issued>2005-10</dcterms:issued> <dcterms:hasPart rdf:resource=""/> <dspace:hasBitstream rdf:resource=""/> <dc:date rdf:datatype="">2012-03-19T12:48:06Z</dc:date> <dcterms:bibliographicCitation>First publ. in: Cell Death and Differentiation ; 12 (2005), 10. - S. 1263-1276</dcterms:bibliographicCitation> <dc:language>eng</dc:language> </rdf:Description> </rdf:RDF>

Downloads since Oct 1, 2014 (Information about access statistics)

May01.pdf 281

This item appears in the following Collection(s)

Search KOPS


My Account