Type of Publication: | Journal article |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-140524 |
Author: | Mayer, Thomas U. |
Year of publication: | 2003 |
Published in: | Trends in Cell Biology ; 13 (2003), 5. - pp. 270-277. - ISSN 0962-8924 |
DOI (citable link): | https://dx.doi.org/10.1016/S0962-8924(03)00077-1 |
Summary: |
Chemical genetics is a research approach that uses small molecules as probes to study protein functions in cells or whole organisms. Here, I review the parallels between classical genetic and chemical-genetic approaches and discuss the merits of small molecules to dissect dynamic cellular processes. I then consider the pros and cons of different screening approaches and specify strategies aimed at identifying and validating cellular target proteins. Finally, I highlight the impact of chemical genetics on our current understanding of cell biology and its potential for the future.
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Subject (DDC): | 570 Biosciences, Biology |
Keywords: | small molecule, Eg5, Kinesin, Chemical Biology |
Link to License: | In Copyright |
MAYER, Thomas U., 2003. Chemical genetics : tailoring tools for cell biology. In: Trends in Cell Biology. 13(5), pp. 270-277. ISSN 0962-8924. Available under: doi: 10.1016/S0962-8924(03)00077-1
@article{Mayer2003Chemi-14052, title={Chemical genetics : tailoring tools for cell biology}, year={2003}, doi={10.1016/S0962-8924(03)00077-1}, number={5}, volume={13}, issn={0962-8924}, journal={Trends in Cell Biology}, pages={270--277}, author={Mayer, Thomas U.} }
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