Publikation: Analysis and expression of a cloned pre-T cell receptor gene
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2009
Autor:innen
Saint-Ruf, Claude
Ungewiss, Katharina
Bruno, Ludovica
Fehling, Hans Jörg
Boehmer, Harald von
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The Journal of Immunology. 2009, 182(9), pp. 5165-5169
Zusammenfassung
The T cell antigen receptor (TCR) p chain regulates early T cell development in the absence of the TCRa chain. The developmentally controlled gene described here encodes the pre-TCRa (pTa) chain, which covalently associates with TCRp and with the CD3 proteins forms a pre-TCR complex that transduces signals in immature thymocytes. Unlike the λ5 pre-B cell receptor protein, the pTa chain is a type I transmembrane protein whose cytoplasmic tail contains two potential phosphorylation sites and a Src homology 3 (SH3)-domain binding sequence. Pre-TCRa transfection experiments indicated that surface expression of the pre-TCR is controlled by additional developmentally regulated proteins. Identification of the pTa gene represents an essential step in the structure-function analysis of the pre-TCR complex.
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570 Biowissenschaften, Biologie
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SAINT-RUF, Claude, Katharina UNGEWISS, Marcus GRÖTTRUP, Ludovica BRUNO, Hans Jörg FEHLING, Harald von BOEHMER, 2009. Analysis and expression of a cloned pre-T cell receptor gene. In: The Journal of Immunology. 2009, 182(9), pp. 5165-5169BibTex
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year={2009},
title={Analysis and expression of a cloned pre-T cell receptor gene},
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journal={The Journal of Immunology},
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<dcterms:abstract xml:lang="eng">The T cell antigen receptor (TCR) p chain regulates early T cell development in the absence of the TCRa chain. The developmentally controlled gene described here encodes the pre-TCRa (pTa) chain, which covalently associates with TCRp and with the CD3 proteins forms a pre-TCR complex that transduces signals in immature thymocytes. Unlike the λ5 pre-B cell receptor protein, the pTa chain is a type I transmembrane protein whose cytoplasmic tail contains two potential phosphorylation sites and a Src homology 3 (SH3)-domain binding sequence. Pre-TCRa transfection experiments indicated that surface expression of the pre-TCR is controlled by additional developmentally regulated proteins. Identification of the pTa gene represents an essential step in the structure-function analysis of the pre-TCR complex.</dcterms:abstract>
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