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Display of 9 of 9 results for the area: Biologie.

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(183.9 KiB)

Biochemical characterization of a variant human medium-chain acyl-CoA dehydrogenase with a disease-associated mutation localized in the active site

Küchler, Burkhard; Abdel Ghany, Abdel Ghany; Bross, Peter; Nandy, Andreas; Rasched, Ihab; Ghisla, Sandro (1999) - Journal article
Published in: Biochemical Journal ; 337 (1999), 2. - pp. 225-230. - ISSN 0264-6021. - eISSN 1470-8728
(2 MiB)

Biochemical characterization of purified, human recombinant Lys304 -> Glu medium-chain acyl-Coa dehydrogenase containing the common disease-causing mutation and comparison with the normal enzyme

Kieweg, Volker; Kräutle, Franz-Georg; Nandy, Andreas; Engst, Stefan; Vock, Petra; Abdel Ghany, Abdel Ghany; Bross, Peter; Gregersen, Niels; Rasched, Ihab; Strauss, Arnold W.; Ghisla, Sandro (1997) - Journal article
Published in: European Journal of Biochemistry ; 246 (1997), 2. - pp. 548-556. - ISSN 0014-2956. - eISSN 1432-1033
(571.8 KiB)

Medium-Long-Chain Chimeric Human Acyl-CoA Dehydrogenase: Medium-Chain Enzyme with the Active Center Base Arrangement of Long-Chain Acyl-CoA Dehydrogenase

Nandy, Andreas; Kieweg, Volker; Kräutle, Franz-Georg; Vock, Petra; Küchler, Burkhard; Bross, Peter; Kim, Jung-Ja P.; Rasched, Ihab; Ghisla, Sandro (1996) - Journal article
Published in: Biochemistry ; 35 (1996), 38. - pp. 12401-12411. - ISSN 0006-2960. - eISSN 1520-4995
(7.2 MiB)

Effects of two mutations detected in medium chain acyl-CoA dehydrogenase (MCAD)-deficient patients on folding, oligomer assembly, and stability of MCAD enzyme

Bross, Peter; Jespersen, Charlotte; Jensen, Thomas G.; Andresen, Brage S.; Kristensen, Morten Juhl; Winter, Vibeke; Nandy, Andreas; Kräutle, Franz-Georg; Ghisla, Sandro; Bolund, Lars; Kim, Jung-Ja P.; Gregersen, Niels (1995) - Journal article
Published in: Journal of Biological Chemistry ; 270 (1995), 17. - pp. 10284-10290. - ISSN 0021-9258
(1.7 MiB)

Characterization of Wild-Type Human Medium-Chain Acyl-CoA Dehydrogenase (MCAD) and Mutant Enzymes Present in MCAD-Deficient Patients by Two-Dimensional Gel Electrophoresis: Evidence for Posttranslational Modification of the Enzyme

Bross, Peter; Jensen, Thomas G.; Andresen, Brage S.; Kjeldsen, Margrethe; Nandy, Andreas; Kølvraa, Steen; Ghisla, Sandro; Rasched, Ihab; Bolund, Lars; Gregersen, Niels (1994) - Journal article
Published in: Biochemical medicine and metabolic biology ; 52 (1994), 1. - pp. 36-44. - ISSN 0885-4505
(770.3 KiB)

Co-overexpression of bacterial GroESL chaperonins partly overcomes non-productive folding and tetramer assembly of E. coli-expressed human medium-chain acyl-CoA dehydrogenase (MCAD) carrying the prevalent disease-causing K304E mutation

Bross, Peter; Andresen, Brage S.; Winter, Vibeke; Kräutle, Franz-Georg; Jensen, Thomas G.; Nandy, Andreas; Kølvraa, Steen; Ghisla, Sandro; Bolund, Lars; Gregersen, Niels (1993) - Journal article
Published in: Biochimica et Biophysica Acta ; 1182 (1993), 3. - pp. 264-274. - ISSN 0925-4439
(391 KiB)

Molecular characterization of medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: identification of a lys329 to glu mutation in the MCAD gene, and expression of inactive mutant enzyme protein in E. coli

Gregersen, Niels; Andresen, Brage S.; Bross, Peter; Winter, Vibeke; Rüdiger, Niels; Engst, Stefan; Christensen, Ernst; Kelly, Daniel P.; Strauss, Arnold W.; Kølvraa, Steen; Bolund, Lars; Ghisla, Sandro (1991) - Journal article
Published in: Human genetics ; 86 (1991), 6. - pp. 545-551. - ISSN 0340-6717. - eISSN 1432-1203
(417.7 KiB)

Characterization of a disease-causing Lys329 to Glu mutation in 16 patients with medium-chain acyl-CoA dehydrogenase deficiency

Gregersen, Niels; Andresen, Brage S.; Bross, Peter; Winter, Vibeke; Rüdiger, Niels; Engst, Stefan; Ghisla, Sandro; Christensen, Ernst; Kelly, Daniel P.; Strauss, Arnold W.; Kølvraa, Steen; Bolund, Lars; Blakemore, Alexandra I. F.; Curtis, D.; Engel, Peter (1991) - Journal article
Published in: Journal of inherited metabolic disease ; 14 (1991), 3. - pp. 314-316. - ISSN 0141-8955. - eISSN 1573-2665
(1.6 MiB)

Characterization of wild-type and an active site mutant of human medium chain acyl-CoA dehydrogenase after expression in Escherichia coli

Bross, Peter; Engst, Stefan; Strauss, Arnold W.; Kelly, Daniel P.; Rasched, Ihab; Ghisla, Sandro (1990) - Journal article
Published in: The Journal of Biological Chemistry ; 265 (1990), 13. - pp. 7116-7119

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