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Display of 10 of 26 results for the area: Biologie.

Now showing items 11-20 of 26

(2 MiB)

Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism

Meiser, Johannes; Delcambre, Sylvie; Wegner, André; Jäger, Christian; Ghelfi, Jenny; Fouquier d'Herouel, Aymeric; Dong, Xiangyi; Schildknecht, Stefan; Leist, Marcel; Hiller, Karsten et al. (2016) - Journal article
Published in: Neurobiology of Disease ; 89 (2016). - pp. 112-125. - ISSN 0969-9961. - eISSN 1095-953X
(1.2 MiB)

Preferential Extracellular Generation of the Active Parkinsonian Toxin MPP⁺ by Transporter-Independent Export of the Intermediate MPDP⁺

Schildknecht, Stefan; Pape, Regina; Meiser, Johannes; Karreman, Christiaan; Strittmatter, Tobias; Odermatt, Meike; Cirri, Erica; Friemel, Anke; Ringwald, Markus; Pasquarelli, Noemi; Ferger, Boris; Brunner, Thomas; Marx, Andreas; Möller, Heiko M; Hiller, Karsten; Leist, Marcel (2015) - Journal article
Published in: Antioxidants & Redox Signaling ; 23 (2015), 13. - pp. 1001-1016. - ISSN 1523-0864. - eISSN 1557-7716
(1.2 MiB)

Prevention of the degeneration of human dopaminergic neurons in an astrocyte co-culture system allowing endogenous drug metabolism

Efremova, Liudmila; Schildknecht, Stefan; Adam, Martina; Pape, Regina; Gutbier, Simon; Hanf, Benjamin; Bürkle, Alexander; Leist, Marcel (2015) - Journal article
Published in: British Journal of Pharmacology ; 172 (2015), 16. - pp. 4119-4132. - ISSN 0007-1188. - eISSN 1476-5381
(6.4 MiB)

A transcriptome-based classifier to identify developmental toxicants by stem cell testing : design, validation and optimization for histone deacetylase inhibitors

Rempel, Eugen; Hoelting, Lisa; Waldmann, Tanja; Balmer, Nina V.; Schildknecht, Stefan; Grinberg, Marianna; Das Gaspar, John Antony; Shinde, Vaibhav; Stöber, Regina; Marchan, Rosemarie; van Thriel, Christoph; Liebing, Julia; Meisig, Johannes; Blüthgen, Nils; Sachinidis, Agapios; Rahnenführer, Jörg; Hengstler, Jan G.; Leist, Marcel (2015) - Journal article
Published in: Archives of Toxicology ; 89 (2015), 9. - pp. 1599-1618. - ISSN 0340-5761. - eISSN 1432-0738
(983.9 KiB)

Toxicity of organic and inorganic mercury species in differentiated human neurons and human astrocytes

Lohren, Hanna; Blagojevic, Lara; Fitkau, Romy; Ebert, Franziska; Schildknecht, Stefan; Leist, Marcel; Schwerdtle, Tanja (2015) - Journal article
Published in: Journal of Trace Elements in Medicine and Biology ; 32 (2015). - pp. 200-208. - ISSN 0946-672X. - eISSN 1878-3252
(4.2 MiB)

Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP⁺

Krug, Anne K.; Gutbier, Simon; Zhao, Liang; Pöltl, Dominik; Kullmann, Cornelius; Ivanova, Violeta; Förster, Sunniva; Jagtap, Smita; Meiser, Johannes; Leparc, German; Schildknecht, Stefan; Adam, Martina; Hiller, Karsten; Farhan, Hesso; Brunner, Thomas; Hartung, Thomas; Sachinidis, Agapios; Leist, Marcel (2014) - Journal article
Published in: Cell Death & Disease ; 5 (2014). - e1222. - eISSN 2041-4889
(2.2 MiB)

Oxidative and nitrative alpha-synuclein modifications and proteostatic stress : implications for disease mechanisms and interventions in synucleinopathies

Schildknecht, Stefan; Gerding, Hanne; Karreman, Christiaan; Drescher, Malte; Lashuel, Hilal A.; Outeiro, Tiago F.; Di Monte, Donato A.; Leist, Marcel (2013) - Journal article
Published in: Journal of Neurochemistry ; 125 (2013), 4. - pp. 491-511. - ISSN 0022-3042. - eISSN 1471-4159
(445.8 KiB)

A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles

Hölting, Lisa; Scheinhardt, Benjamin; Bondarenko, Olesja; Schildknecht, Stefan; Kapitza, Marion; Tanavde, Vivek; Tan, Betty; Lee, Qian Yi; Mecking, Stefan; Leist, Marcel; Kadereit, Suzanne (2013) - Journal article
Published in: Archives of Toxicology ; 87 (2013), 4. - pp. 721-733. - ISSN 0340-5761. - eISSN 1432-0738
(553.6 KiB)

The NOX1/4 inhibitor GKT136901 as selective and direct scavenger of peroxynitrite

Schildknecht, Stefan; Weber, Annemarie; Gerding, Hanne; Pape, Regina; Robotta, Marta; Drescher, Malte; Marquardt, Andreas; Daiber, Andreas; Ferger, Boris; Leist, Marcel (2013) - Journal article
Published in: Current Medicinal Chemistry ; 21 (2013), 3. - pp. 365-376. - ISSN 0929-8673. - eISSN 1875-533X
(6.1 MiB)

Generation of Genetically-Modified Human Differentiated Cells for Toxicological Tests and the Study of Neurodegenerative Diseases

Schildknecht, Stefan; Karreman, Christiaan; Pöltl, Dominik; Efremova, Liudmila; Kullmann, Cornelius; Gutbier, Simon; Krug, Anne-Kathrin; Scholz, Diana; Gerding, Hanne R.; Leist, Marcel (2013) - Journal article
Published in: Alternatives to animal experimentation : ALTEX ; 30 (2013), 4. - pp. 427-444. - ISSN 1868-596X

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